(+/-)-4-[4-methyl-3,4-dihydro-1,4-benzoxazin-2-yl]methoxybenzaldehyde | 223608-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (+/-)-4-[4-methyl-3,4-dihydro-1,4-benzoxazin-2-yl]methoxybenzaldehyde
• 英文别名: 4-[4-Methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxybenzaldehyde；4-[(4-Methyl-2,3-dihydro-1,4-benzoxazin-2-yl)methoxy]benzaldehyde
• CAS: 223608-15-9
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: BJRKBGLIKADETD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-Dihydro-4-methyl-2H-1,4-benzoxazin-2-ylmethanol 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 (+/-)-4-[4-methyl-3,4-dihydro-1,4-benzoxazin-2-yl]methoxybenzaldehyde
  参考文献：
  名称：

  Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents

  摘要：

  本发明涉及新型抗肥胖和降低胆固醇的化合物、它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和药学上可接受的含有它们的组合物。更具体地，本发明涉及一般式(I)的新型β-芳基-α-氧代取代烷基羧酸、它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和药学上可接受的含有它们的组合物。

  公开号：

  US07348426B1

文献信息

• Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
  申请人：Reddy-Cheminor, Inc.

  公开号：US06265401B1

  公开（公告）日：2001-07-24

  Compounds of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes caused by insulin resistance or impaired glucose tolerance. The compounds can also be used to reduce cholesterol, body weight, blood glucose, triglycerides and free fatty acids in the blood.

  式(I)的化合物、其互变异构体、立体异构体、多晶型、药学上可接受的盐或药学上可接受的溶剂，可用于预防或治疗由胰岛素抵抗或糖耐量受损引起的糖尿病或由胰岛素抵抗或糖耐量受损引起的糖尿病并发症。这些化合物还可用于降低血液中的胆固醇、体重、血糖、甘油三酯和游离脂肪酸水平。
• Novel bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
  申请人：DR. REDDY'S RESEARCH FOUNDATION AND REDDY-CHEMINOR, INC.

  公开号：US20010051619A1

  公开（公告）日：2001-12-13

  Compounds of formula (I) 1 its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes caused by insulin resistance or impaired glucose tolerance. The compounds can also be used to reduce cholesterol, body weight, blood glucose, triglycerides and free fatty acids in the blood.

  式（I）的化合物及其互变异构体、立体异构体、多晶形态、药学上可接受的盐或药学上可接受的溶剂，可用于预防或治疗由胰岛素抵抗或糖耐量受损引起的糖尿病或由胰岛素抵抗或糖耐量受损引起的糖尿病并发症。这些化合物还可用于降低血液中的胆固醇、体重、血糖、甘油三酯和游离脂肪酸。
• BICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：EP1082313A1

  公开（公告）日：2001-03-14
• SUBSTITUTED BICYCLIC HETEROCYCLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTIOBESITY AND HYPOCHOLESTEROLEMIC AGENTS
  申请人：Dr. Reddy's Research Foundation

  公开号：EP1175412A1

  公开（公告）日：2002-01-30
• US6265401B1
  申请人：——

  公开号：US6265401B1

  公开（公告）日：2001-07-24