N-allyl-4-methyl-N'-(pentan-3-ylidene)benzenesulfonohydrazide | 1338091-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-allyl-4-methyl-N'-(pentan-3-ylidene)benzenesulfonohydrazide
• 英文别名: 4-methyl-N-(pentan-3-ylideneamino)-N-prop-2-enylbenzenesulfonamide
• CAS: 1338091-93-2
• 化学式: C₁₅H₂₂N₂O₂S
• 分子量: 294.418
• InChiKey: IQPQJTCYCZZAKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-戊酮对-甲苯磺酰腙 、 3-溴丙烯 在 caesium carbonate 作用下， 反应 1.0h， 以94%的产率得到N-allyl-4-methyl-N'-(pentan-3-ylidene)benzenesulfonohydrazide
  参考文献：
  名称：

  Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

  摘要：

  A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.056

文献信息

• Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill
  作者：Pierrick Nun、Charlotte Martin、Jean Martinez、Frédéric Lamaty

  DOI：10.1016/j.tet.2011.07.056

  日期：2011.10

  A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones. (C) 2011 Elsevier Ltd. All rights reserved.