2-amino-1-(4-chlorophenyl)-1,3-propanediol | 50731-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-1-(4-chlorophenyl)-1,3-propanediol
• 英文别名: 2-Amino-1-(4-chlorophenyl)propane-1,3-diol
• CAS: 50731-32-3
• 化学式: C₉H₁₂ClNO₂
• 分子量: 201.653
• InChiKey: SHJKCQPLVOAQDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• METHOD FOR RESOLUTION OF A MIXTURE OF PINOCEMBRIN OPTICAL ISOMERS, ESPECIALLY A PINOCEMBRIN RACEMATE
  申请人：Wu Song

  公开号：US20100261916A1

  公开（公告）日：2010-10-14

  The present invention relates to a method for resolution of a mixture of pinocembrin optical isomers, in particular a pinocembrin racemate, using a chiral primary amine or a chiral sulfinamide. The present invention also relates to a (R)-(+)-pinocembrin obtained by the method.

  本发明涉及一种利用手性初级胺或手性亚砜解析一种品可木酮光学异构体混合物，特别是品可木酮外消旋体的方法。本发明还涉及一种通过该方法获得的(R)-(+)-品可木酮。
• METHODS FOR RESOLUTION OF THE MIXTURE OF THE OPTICAL ISOMERS, ESPECIALLY THE RACEMATE OF PINOCEMBRIN
  申请人：CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.

  公开号：EP2221300B1

  公开（公告）日：2014-01-08
• PROCESS FOR PREPARING THE COMPOUND 2,2-DIFLUORO-N-((1R,2S)-3-FLUORO-1-HYDROXY-1-(4-(6-(S-METHYLSULFONIMIDOYL)PYRIDIN-3-YL)PHENYL)PROPAN-2-YL)ACETAMIDE
  申请人：Zoetis Services LLC

  公开号：EP3856718A1

  公开（公告）日：2021-08-04
• US8399691B2
  申请人：——

  公开号：US8399691B2

  公开（公告）日：2013-03-19
• [EN] PROCESS FOR PREPARING THE COMPOUND 2,2-DIFLUORO-N-((1R,2S)-3-FLUORO-1-HYDROXY-1-(4-(6-(S-METHYLSULFONIMIDOYL)PYRIDIN-3-YL)PHENYL)PROPAN-2-YL)ACETAMIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DU COMPOSÉ 2,2-DIFLUORO-N-((1R,2S)-3-FLUORO-1-HYDROXY-1-(4-(6-(S-MÉTHYLSULFONIMIDOYL)PYRIDIN-3-YL)PHÉNYL)PROPAN-2-YL)ACÉTAMIDE
  申请人：ZOETIS SERVICES LLC

  公开号：WO2020068607A1

  公开（公告）日：2020-04-02

  The present invention provides a novel process for preparing a diastereomeric mixture of the phenicol of Formula (1), its use for the treatment of bacterial infections in animals, and veterinary compositions containing the Formula (1) compound, diastereomers thereof, and veterinary acceptable salts thereof.