N,N-bis(4-hydroxyphenyl)acetamide | 1075742-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-bis(4-hydroxyphenyl)acetamide
• CAS: 1075742-56-1
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: GPORWCRXAOCCFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-bis(4-hydroxyphenyl)acetamide 在 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  电晕[6]芳烃的合成，结构和性质及其在结晶态与阴离子的组装

  摘要：

  系统地研究了新型日冕芳烃的合成，构象结构，电子性质和阴离子络合。许多含有氮原子与O，S，SO 2和CH 2的不同组合的电晕[4]芳烃[2]四嗪由于基于容易获得的芳族二亲核试剂和3,6-二氯四嗪的有效亲核芳族取代反应，通过片段偶联策略方便地合成了桥联单元。所得的大环采用冠状构象结构，其中氮桥与羰基形成共轭，而其他杂原子与四嗪键合。CV和DPV测量结果表明，含四嗪的冠氮芳烃缺乏电子，还原电位为-896至-960 mV。N 2，O 4-电晕[4]芳烃[2]四嗪主要由于非共价阴离子-π吸引相互作用而与具有不同几何形状和形状的阴离子形成络合物，从而产生固态的各种组装结构。

  DOI：

  10.1021/acs.joc.7b03136
• 作为产物：
  描述：

  N,N-bis(4-methoxyphenyl)acetamide 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 N,N-bis(4-hydroxyphenyl)acetamide
  参考文献：
  名称：

  Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton

  摘要：

  Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.004

文献信息

• HYDROXY-PHENOXYETHER POLYMERS IN PAPERMAKING
  申请人：Advanced Plastics Technologies, Ltd

  公开号：EP1278912A2

  公开（公告）日：2003-01-29
• [EN] HYDROXY-PHENOXYETHER POLYMERS IN PAPERMAKING<br/>[FR] POLYMERES D'HYDROXY-PHENOXYETHER UTILISES DANS LA FABRICATION DU PAPIER
  申请人：ADVANCED PLASTICS TECHNOLOGIES

  公开号：WO2001046523A2

  公开（公告）日：2001-06-28

  Paper comprised of suitable amounts of a hydroxy-phenoxyether polymer is effective to provide that paper with an increase in sizing or strength. Such paper may be prepared by intermixing dispersions or solutions of hydroxy-phenoxyether polymer with the pulp slurry or web during papermaking, or by application to formed paper. Paper may be coated or laminated by applying such dispersions or solutions.
• Synthesis, Structure, and Properties of Corona[6]arenes and Their Assembly with Anions in the Crystalline State
  作者：Meng-Yao Zhao、De-Xian Wang、Mei-Xiang Wang

  DOI：10.1021/acs.joc.7b03136

  日期：2018.2.2

  The synthesis, conformational structure, electronic property, and anion complexation of novel coronarenes were systematically studied. A number of corona[4]arene[2]tetrazines that contain different combinations of nitrogen atoms with O, S, SO2, and CH2 as bridging units were synthesized conveniently by means of a fragment coupling strategy based on efficient nucleophilic aromatic substitution reaction

  系统地研究了新型日冕芳烃的合成，构象结构，电子性质和阴离子络合。许多含有氮原子与O，S，SO 2和CH 2的不同组合的电晕[4]芳烃[2]四嗪由于基于容易获得的芳族二亲核试剂和3,6-二氯四嗪的有效亲核芳族取代反应，通过片段偶联策略方便地合成了桥联单元。所得的大环采用冠状构象结构，其中氮桥与羰基形成共轭，而其他杂原子与四嗪键合。CV和DPV测量结果表明，含四嗪的冠氮芳烃缺乏电子，还原电位为-896至-960 mV。N 2，O 4-电晕[4]芳烃[2]四嗪主要由于非共价阴离子-π吸引相互作用而与具有不同几何形状和形状的阴离子形成络合物，从而产生固态的各种组装结构。
• Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton
  作者：Kiminori Ohta、Yuki Chiba、Takumi Ogawa、Yasuyuki Endo

  DOI：10.1016/j.bmcl.2008.08.004

  日期：2008.9

  Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. (C) 2008 Elsevier Ltd. All rights reserved.