1-(4-chlorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-chlorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanol
• 英文别名: 1-(4-chlorophenyl)-1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol
• 化学式: C₁₆H₁₃ClFN₃O
• 分子量: 317.74
• InChiKey: XSPKMOFEAJKMSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1H-1,2,4-三唑 生成 1-(4-chlorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanol
  参考文献：
  名称：

  PARRY, KELTH PETER;WORTHINGTON, PAUL ANTHONY;RATHMELL, WILLIAM GEORGE

  摘要：

  DOI：

文献信息

• Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0047057A2

  公开（公告）日：1982-03-10

  Compounds of formula: which are cis- and trans-isomers, and mixtures thereof, wherein R1 and R2 which may be the same or different are alkyl, cycloalkyl or optionally substituted phenyl and their acid addition salts and metal complexes. Tre compounds have fungicidal activity useful in the agricultural and pharmaceutical fields. They are also capable of regulating plant growth.

  式化合物 顺式异构体和反式异构体，以及它们的混合物，其中 R1 和 R2 可以是相同或不同的烷基、环烷基或任选取代的苯基，以及它们的酸加成盐和金属络合物。Tre 化合物具有杀菌活性，可用于农业和医药领域。它们还能调节植物生长。
• Triazole compounds, a process for preparing them, their use as plant fungicides and plant growth regulators and compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0047594A2

  公开（公告）日：1982-03-17

  Compounds of formula: and stereoisomers thereof, wherein R1 is alkyl, cycloalkyl or optionally substituted phenyl and R2 is phenyl or benzyl, each optionally substituted; and their acid addition salts, ethers, esters and metal complexes; have fungicidal and plant growth regulating activity.

  式化合物及其立体异构体 及其立体异构体，其中 R1 是烷基、环烷基或任选取代的苯基，R2 是苯基或苄基，各自任选取代；以及它们的酸加成盐、醚、酯和金属络合物；具有杀菌和植物生长调节活性。
• Use of triazolylethanol derivatives and their compositions as non-agricultural fungicides
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0131684B1

  公开（公告）日：1992-03-11
• ——
  作者：

  DOI：——

  日期：——
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.