2-(2-nitrooxyethoxy)ethyl 4-nitrophenyl carbonate | 1006866-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-nitrooxyethoxy)ethyl 4-nitrophenyl carbonate
• 英文别名: 2-[2-(Nitrooxy)ethoxy]ethyl 4-nitrophenyl carbonate；2-(2-nitrooxyethoxy)ethyl (4-nitrophenyl) carbonate
• CAS: 1006866-24-5
• 化学式: C₁₁H₁₂N₂O₉
• 分子量: 316.224
• InChiKey: KIEIQIBATLNEDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  146
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-(2-nitrooxyethoxy)ethyl 4-nitrophenyl carbonate 、 BOC-L-丝氨酸 在 scandium tris(trifluoromethanesulfonate) 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以80%的产率得到2,2-dimethyl-15-nitrooxy-4,9-dioxo-3,8,10,13-tetraoxa-5-aza-pentadecane-6-carboxylic acid
  参考文献：
  名称：

  WO2008/95841

  摘要：

  公开号：

文献信息

• Nitrate esters of aminoalcohols
  申请人：Herold Peter

  公开号：US20090318432A1

  公开（公告）日：2009-12-24

  The application relates to novel nitrate ester derivatives of substituted aminoalcohols of the general formula (I), wherein R 1 , R 2 , R 3 , V, X, Y and Z 0 have the meanings explained in more detail in the description, to a process for their preparation and to the use of these compounds as therapeutics in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage age accompanying high blood pressure.

  该申请涉及一种新型硝酸酯衍生物，其为通式（I）中的取代氨基醇衍生物，其中R1、R2、R3、V、X、Y和Z0的含义在说明中有更详细的解释，以及它们的制备方法和将这些化合物作为治疗剂用于心血管疾病，特别是高血压和伴随高血压的血管和器官损伤的用途。
• NITRATE ESTERS OF PIPERIDINES
  申请人：Herold Peter

  公开号：US20090325947A1

  公开（公告）日：2009-12-31

  The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R 1 , R 2 , R 3 , X, Y and Z 0 , and m, n, p and q have the meanings explained in more detail in the description, a process for their preparation and the use of these compounds as a curative agent in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage accompanying high blood pressure.

  该申请涉及一种新的硝酸酯衍生物，其为通式（I）中取代哌啶的衍生物，其中R1、R2、R3、X、Y和Z0，以及m、n、p和q的含义在说明中有更详细的解释，以及其制备方法和将这些化合物用作心血管疾病的治疗剂，特别是用于高血压和伴随高血压的血管和器官损伤。
• NITRIC OXIDE DONOR COMPOUNDS
  申请人：Almirante Nicoletta

  公开号：US20100099729A1

  公开（公告）日：2010-04-22

  The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolismsdysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.

  本发明涉及一种一氧化氮供体化合物及其在治疗心血管疾病、炎症、疼痛、发热、胃肠道疾病、眼科疾病、肝脏疾病、肾脏疾病、呼吸系统疾病、免疫系统疾病、骨代谢功能障碍、中枢神经系统和周围神经系统疾病、性功能障碍、感染性疾病、抑制血小板聚集和血小板粘附、治疗由异常细胞增殖引起的病理性状况以及血管疾病方面的应用。该发明还涉及包含本发明中至少一种一氧化氮释放化合物的组合物，以及包含本发明中至少一种一氧化氮释放化合物和至少一种治疗剂的组合物。
• Nitric oxide donor compounds
  申请人：NICOX S.A.

  公开号：US09266820B2

  公开（公告）日：2016-02-23

  The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metabolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.

  本发明涉及一种硝酸盐供体化合物及其用于治疗心血管疾病、炎症、疼痛、发热、胃肠道疾病、眼科疾病、肝脏疾病、肾脏疾病、呼吸系统疾病、免疫系统疾病、骨代谢紊乱、中枢和外周神经系统疾病、性功能障碍、感染性疾病、用于抑制血小板聚集和血小板粘附、用于治疗由异常细胞增殖引起的病理状况的组合物。本发明还涉及包含本发明中至少一种硝酸盐释放化合物的组合物以及包含本发明中至少一种硝酸盐释放化合物和至少一种治疗剂的组合物。
• NITRATE ESTERS OF AMINOALCOHOLS
  申请人：Novartis AG

  公开号：EP2061751A1

  公开（公告）日：2009-05-27