tert-Butyl 2,6-diazaspiro[4.5]dec-8-ene-2-carboxylate | 918896-20-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-Butyl 2,6-diazaspiro[4.5]dec-8-ene-2-carboxylate
• 英文别名: tert-butyl 2,6-diazaspiro[4.5]dec-8-ene-2-carboxylate
• CAS: 918896-20-5
• 化学式: C₁₃H₂₂N₂O₂
• 分子量: 238.33
• InChiKey: KRBHPIGXPULALN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-叔丁氧碳基-3-吡咯烷酮 在 对甲苯磺酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 tert-Butyl 2,6-diazaspiro[4.5]dec-8-ene-2-carboxylate
  参考文献：
  名称：

  An expedient route to diaza-spirocycles utilizing a sequential multicomponent α-aminoallylation/ring-closing metathesis strategy

  摘要：

  A general method for the preparation of diaza-spirocycles is reported. This method used an olefin metathesis in order to construct the desired spirocyclic framework. Beginning with commercially available protected amino ketones, this strategy ultimately produced pharmacologically relevant diaza-scaffolds in an efficient and high-yielding process. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.10.011

文献信息

• An expedient route to diaza-spirocycles utilizing a sequential multicomponent α-aminoallylation/ring-closing metathesis strategy
  作者：Vijaya Gracias、Alan F. Gasiecki、Joel D. Moore、Irini Akritopoulou-Zanze、Stevan W. Djuric

  DOI：10.1016/j.tetlet.2006.10.011

  日期：2006.12

  A general method for the preparation of diaza-spirocycles is reported. This method used an olefin metathesis in order to construct the desired spirocyclic framework. Beginning with commercially available protected amino ketones, this strategy ultimately produced pharmacologically relevant diaza-scaffolds in an efficient and high-yielding process. (c) 2006 Elsevier Ltd. All rights reserved.