N-(1H-苯并咪唑-6-基)丙烯酰胺 | 34443-03-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: N-(1H-苯并咪唑-6-基)丙烯酰胺
• 英文名称: N-(1H-benzo[d]imidazol-6-yl)acrylamide
• 英文别名: N-(3H-benzimidazol-5-yl)prop-2-enamide
• CAS: 34443-03-3
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: LBPLJQZONVVTJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  555.5±32.0 °C(Predicted)
• 密度：
  1.339±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-C-(diethoxyphosphoryl)nitrone 、 N-(1H-苯并咪唑-6-基)丙烯酰胺 以 甲苯 为溶剂， 反应 24.0h， 以29%的产率得到diethyl trans-5-(1H-benzo[d]imidazol-6-ylcarbamoyl)-2-methylisoxazolidin-3-yl-3-phosphonate
  参考文献：
  名称：

  Novel 5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as Nucleotide Analogues

  摘要：

  A series of 5-substituted 3-phosphonylated isoxazolidines have been obtained via cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N-heteroaromatic acrylamides. Good trans/cis diastereoselectivities (d.e. 58-76%) of isomeric (3-diethoxyphosphoryl)isoxazolidines were observed. cis- and trans-Isoxazolidine phosphonates were evaluated for their antiviral activity against a broad range of DNA and RNA viruses but were found inactive. Their cytostatic activity toward L1210, CEM, and HeLa cells was also established, and compounds cis-12r and trans-11r having a 2,2-difluorobenzo[d][1,3]dioxole moiety slightly inhibited proliferation of HeLa cells at IC50 values of 186 and 179 μM, respectively.

  DOI：

  10.1080/15257770.2014.909046
• 作为产物：
  描述：

  丙烯酰氯 、 5-氨基苯并咪唑 在 三乙胺 作用下， 反应 24.0h， 以28%的产率得到N-(1H-苯并咪唑-6-基)丙烯酰胺
  参考文献：
  名称：

  Novel 5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as Nucleotide Analogues

  摘要：

  A series of 5-substituted 3-phosphonylated isoxazolidines have been obtained via cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N-heteroaromatic acrylamides. Good trans/cis diastereoselectivities (d.e. 58-76%) of isomeric (3-diethoxyphosphoryl)isoxazolidines were observed. cis- and trans-Isoxazolidine phosphonates were evaluated for their antiviral activity against a broad range of DNA and RNA viruses but were found inactive. Their cytostatic activity toward L1210, CEM, and HeLa cells was also established, and compounds cis-12r and trans-11r having a 2,2-difluorobenzo[d][1,3]dioxole moiety slightly inhibited proliferation of HeLa cells at IC50 values of 186 and 179 μM, respectively.

  DOI：

  10.1080/15257770.2014.909046

文献信息

• SELECTIVE KINASE INHIBITORS
  申请人：YM BioSciences Australia Pty Ltd

  公开号：EP1704145B1

  公开（公告）日：2012-06-13
• PRESSURE-SENSITIVE ADHESIVE COMPOSITION, PRESSURE-SENSITIVE ADHESIVE SHEET AND METHOD FOR PRODUCING PRESSURE-SENSITIVE ADHESIVE SHEET
  申请人：NIWA Masahito

  公开号：US20110159195A1

  公开（公告）日：2011-06-30

  The present invention relates to an acrylic pressure-sensitive adhesive composition comprising a copolymerization reaction product of a monomer mixture satisfying the following both conditions: (a) the monomer mixture includes a monomer m1 in an amount of 50% by mass or more based on whole monomer components constituting the monomer mixture, wherein the monomer m1 is an alkyl (meth)acrylate represented by the following formula (I): CH 2 ═C(R 1 )COOR 2 (I) wherein R 1 represents a hydrogen atom or a methyl group, and R 2 represents an alkyl group having from 1 to 20 carbon atoms; and (b) the monomer mixture includes a monomer m2 in an amount of 12% by mass or more based on the whole monomer components constituting the monomer mixture, or a monomer m2 and a monomer m3 in an amount in total of 12% by mass or more based on the whole monomer components constituting the monomer mixture, wherein the monomer m2 is an imidazole group-containing unsaturated monomer, and the monomer m3 is an amide group-containing unsaturated monomer.