N-(2,3-二羟基丙基)二苯胺 | 168611-98-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2,3-二羟基丙基)二苯胺
• 英文名称: N-(2,3-dihydroxypropyl)diphenylamine
• 英文别名: 3-(diphenylamino)propane-1,2-diol；3-(N-phenylanilino)propane-1,2-diol
• CAS: 168611-98-1
• 化学式: C₁₅H₁₇NO₂
• 分子量: 243.305
• InChiKey: QXJMTHSWSAMWTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,3-二羟基丙基)二苯胺 在 4-甲苯磺酸酐 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 以57%的产率得到N-(2,3-epoxypropyl)diphenylamine
  参考文献：
  名称：

  Titanocene(III)-Catalyzed Formation of Indolines and Azaindolines

  摘要：

  Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.

  DOI：

  10.1021/ol801860s
• 作为产物：
  描述：

  N-烯丙基-N-苯基苯胺 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 四氢呋喃 、 丙酮 、 甲苯 为溶剂， 以86%的产率得到N-(2,3-二羟基丙基)二苯胺
  参考文献：
  名称：

  Titanocene(III)-Catalyzed Formation of Indolines and Azaindolines

  摘要：

  Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.

  DOI：

  10.1021/ol801860s

文献信息

• CHEMOSELECTIVE ENRICHMENT FOR COMPOUND ISOLATION
  申请人：Indiana University Research and Technology Corporation

  公开号：US20140107328A1

  公开（公告）日：2014-04-17

  Chemoselective isolation of aliphatic hydroxyl group-containing and aromatic hydroxyl group-containing compounds is accomplished via formation of polymeric siloxyl ethers. Chemoselective release of aliphatic hydroxyl group-containing and aromatic hydroxyl group-containing compounds from polymeric siloxyl reagents is described.

  通过形成聚合硅氧烷醚，可以实现对含有脂肪烃羟基和芳香族羟基化合物的化学选择性分离。本文描述了从聚合硅氧烷试剂中选择性释放含有脂肪烃羟基和芳香族羟基化合物的化学选择性。
• METHOD FOR PRODUCING CATIONIC LIPID
  申请人：NOF Corporation

  公开号：EP3231790A1

  公开（公告）日：2017-10-18

  To provide an industrial method for producing a cationic lipid, which does not require a special equipment and by which a cationic lipid of high purity can be efficiently obtained. A cationic lipid represented by formula (1) is mixed with a tetraalkylammonium salt having X- in an organic solvent, and a filtrate obtained by separating a tetraalkylammonium iodide deposited by filtration is concentrated to deposit a tetraalkylammonium iodide, thereby obtaining a cationic lipid represented by formula (2):

  提供一种生产阳离子脂质的工业方法，该方法不需要特殊设备，并能有效地获得高纯度的阳离子脂质。将式（1）表示的阳离子脂质与具有 X-的四烷基铵盐在有机溶剂中混合，并将通过过滤分离沉积的四烷基碘化铵而得到的滤液浓缩沉积四烷基碘化铵，从而得到式（2）表示的阳离子脂质：
• Titanocene(III)-Catalyzed Formation of Indolines and Azaindolines
  作者：Peter Wipf、John P. Maciejewski

  DOI：10.1021/ol801860s

  日期：2008.10.2

  Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.
• Synthesis and thermal reactions of N-(2,3-epoxypropyl)diphenylamine
  作者：B. Barvainiene、A. Stanisauskaite、V. Getautis

  DOI：10.1007/s10593-007-0117-7

  日期：2007.6
• SCREENING METHODS FOR AMYLOID BETA MODULATORS
  申请人：Slon-Usakiewicz Jacek

  公开号：US20110028719A1

  公开（公告）日：2011-02-03

  The present invention relates to methods for screening, identifying, and/or quantifying modulators of amyloid and/or aggregates, fibrils or components thereof, in particular modulators of amyloid β-peptide (Aβ) or Aβ fibrils. Aspects of the invention provide methods for screening putative modulators against an Amyloid target, in particular an Aβ target, so as to determine which modulators bind to or interact with the target, or interfere with the interaction of an indicator agent and the target. Particular aspects of the invention employ mass spectrometric methods for the screening of an Amyloid target against compound libraries, in particular mixtures of compounds or combinatorial libraries.