ethyl 7-(3-amino-2,4,6-triiodophenyl)heptanoate | 161466-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 7-(3-amino-2,4,6-triiodophenyl)heptanoate
• CAS: 161466-39-3
• 化学式: C₁₅H₂₀I₃NO₂
• 分子量: 627.043
• InChiKey: LZRSTVREZNQBLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 7-(3-amino-2,4,6-triiodophenyl)heptanoate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以85%的产率得到7-(3-amino-2,4,6-triiodophenyl)heptanoic acid
  参考文献：
  名称：

  Polyiodinated Triglyceride Analogs as Potential Computed Tomography Imaging Agents for the Liver

  摘要：

  A series of glyceryl 2-oleoyl 1,3-bis[omega-(3-amino-2,4,6-triiodophenyl]) alkanoates was synthesized, radioiodinated with iodine-125, emulsified, and evaluated for their ability to selectively localize in the liver for potential use as hepatographic agents in computed tomography. All seven analogs displayed rapid liver uptake wherein between 65 and 78% of the injected dose accumulated in the liver by 30 min. Liver values ranged from 46 to 93% 3 h after injection which corresponded to liver to blood ratios ranging from 21 to 450. Moreover, subsequent elimination of radioactivity from the liver was nearly linear with respect to alkyl chain length. Analogs with longer alkyl chain length were eliminated from the liver more rapidly than their shorter chain counterparts. Because of their biochemical similarities to naturally occurring triglycerides, these novel analogs may prove useful not only for high-resolution anatomic imaging of focal liver lesions, but also for evaluating a variety of diffuse diseases known to affect hepatic function and biochemistry.

  DOI：

  10.1021/jm00004a010
• 作为产物：
  描述：

  ethyl 7-(3-aminophenyl)heptanoate 在 盐酸 、 一氯化碘 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以70%的产率得到ethyl 7-(3-amino-2,4,6-triiodophenyl)heptanoate
  参考文献：
  名称：

  Polyiodinated Triglyceride Analogs as Potential Computed Tomography Imaging Agents for the Liver

  摘要：

  A series of glyceryl 2-oleoyl 1,3-bis[omega-(3-amino-2,4,6-triiodophenyl]) alkanoates was synthesized, radioiodinated with iodine-125, emulsified, and evaluated for their ability to selectively localize in the liver for potential use as hepatographic agents in computed tomography. All seven analogs displayed rapid liver uptake wherein between 65 and 78% of the injected dose accumulated in the liver by 30 min. Liver values ranged from 46 to 93% 3 h after injection which corresponded to liver to blood ratios ranging from 21 to 450. Moreover, subsequent elimination of radioactivity from the liver was nearly linear with respect to alkyl chain length. Analogs with longer alkyl chain length were eliminated from the liver more rapidly than their shorter chain counterparts. Because of their biochemical similarities to naturally occurring triglycerides, these novel analogs may prove useful not only for high-resolution anatomic imaging of focal liver lesions, but also for evaluating a variety of diffuse diseases known to affect hepatic function and biochemistry.

  DOI：

  10.1021/jm00004a010

文献信息

• Iodine-based particles
  申请人：Nanoprobes, Inc.

  公开号：US10918742B2

  公开（公告）日：2021-02-16

  Described herein are iodine-based particles which can be used as contrast agents for x-ray radiology. Also described herein are methods, software modules and hardware modules for imaging iodine-based particles.

  本文描述了可用作 X 射线放射学造影剂的碘基粒子。本文还描述了碘基粒子成像的方法、软件模块和硬件模块。
• IODINE-BASED PARTICLES
  申请人：Nanoprobes, Inc.

  公开号：US20170274101A1

  公开（公告）日：2017-09-28

  Described herein are iodine-based particles which can be used as contrast agents for x-ray radiology. Also described herein are methods, software modules and hardware modules for imaging iodine-based particles.
• [EN] IODINE-BASED PARTICLES<br/>[FR] PARTICULES À BASE D'IODE
  申请人：NANOPROBES INC

  公开号：WO2017165841A1

  公开（公告）日：2017-09-28

  Described herein are iodine-based particles which can be used as contrast agents for x-ray radiology. Also described herein are methods, software modules and hardware modules for imaging iodine-based particles.