N-(2,4,6-三氯苯基)苯甲肼酰氯 | 25939-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2,4,6-三氯苯基)苯甲肼酰氯
• 中文别名: 苯酰氯-(2,4,6-三氯苯基)腙；杀螨腙
• 英文名称: N-(2,4,6-trichloro)phenylbenzhydrazidoyl chloride
• 英文别名: N'-(2,4,6-trichloro-phenyl)-benzohydrazonoyl chloride；(α-Chlor-benzyliden)-2.4.6-trichlor-phenylhydrazin；N'-(2,4,6-Trichlor-phenyl)-benzohydrazonoylchlorid；benzoyl chloride (2,4,6-trichlorophenyl)hydrazone；Benz-<2.4.6-trichlor-phenylhydrazid>-chlorid；N-(α-Chlorbenzyliden)-2,4,6-trichlorphenylhydrazin；N-(2,4,6-trichlorophenyl)benzenecarbohydrazonoyl chloride
• CAS: 25939-05-3
• 化学式: C₁₃H₈Cl₄N₂
• 分子量: 334.032
• InChiKey: QVMATSPQIBFRPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  98°C
• 沸点：
  490.16°C (rough estimate)
• 密度：
  1.5087 (rough estimate)
• 稳定性/保质期：
  燃烧会产生有毒的氮氧化物和氯化物气体。

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090
• 储存条件：
  库房应保持通风、低温和干燥，并与食品原料分开储存和运输。

制备方法与用途

类别：农药

毒性分级：中毒

急性毒性：口服-大鼠 LD50: 1050 毫克/公斤

可燃性危险特性：燃烧时会产生有毒的氮氧化物和氯化物气体

储运特性：应存放在通风、低温和干燥的库房内，并与食品原料分开存放和运输

灭火剂：干粉、泡沫或砂土

反应信息

• 作为反应物：
  描述：

  N-(2,4,6-三氯苯基)苯甲肼酰氯 在 乙醇 、 锌 作用下， 生成 2,4,6-三氯苯肼
  参考文献：
  名称：

  Humphries; Humble; Evans, Journal of the Chemical Society, 1925, vol. 127, p. 1306

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲醛苯腙 在 氯 作用下， 生成 N-(2,4,6-三氯苯基)苯甲肼酰氯
  参考文献：
  名称：

  Humphries; Humble; Evans, Journal of the Chemical Society, 1925, vol. 127, p. 1306

  摘要：

  DOI：

文献信息

• Anthelmintic methods employing benzoyl chloride phenylhydrazones
  申请人：The Upjohn Company

  公开号：US03932661A1

  公开（公告）日：1976-01-13

  Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites, and they have also been found to be effective, broad-spectrum anthelmintics for suppressing parasitic worms in animals, particularly sheep. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive. A new class of pentahalobenzoyl chloride phenylhydrazones is described, particularly pentafluorobenzoyl chloride phenylhydrazones. The compounds are prepared by reacting a benzoic acid phenylhydrazide with phosphorus pentachloride to obtain a benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct chlorination of a benzaldehyde phenylhydrazone. Methods of using the new compounds and new anthelmintic formulations are described. The new compound p-toluoyl chloride phenylhydrazone is effective against worms at rates at least as low as 100 mg./kg. of body weight in sheep.

  某些苯甲酰氯苯基肼已被发现对昆虫和螨具有活性，它们还被发现对动物，特别是羊体内的寄生虫蠕虫有抑制作用，是有效的广谱驱虫剂。苯甲酰环和苯基肼环可以被卤素原子、硝基团或含有1至6个碳原子的烷基取代。描述了一类新的五卤苯甲酰氯苯基肼，特别是五氟苯甲酰氯苯基肼。通过将苯甲酸苯基肼与五氯化磷反应以获得苯甲酰氯（二氯磷基）苯基肼，然后将其与酚反应以产生所需的苯甲酰氯苯基肼来制备这些化合物。其中的一些化合物可以通过对苯甲醛苯基肼进行直接氯化制备。描述了使用新化合物和新驱虫剂配方的方法。新化合物对羊体重至少为100毫克/千克的剂量具有对抗蠕虫的有效性。
• Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay
  作者：Byung H Lee、Fred E Dutton、Michael F Clothier、Jerry W Bowman、John P Davis、Sandra S Johnson、Eileen M Thomas、Marjorie R Zantello、Erich W Zinser、James C McGuire、David P Thompson、Timothy G Geary

  DOI：10.1016/s0960-894x(99)00267-x

  日期：1999.6

  suum), we prepared two series of analogs. Only the series containing the thiadiazole ring had potencies comparable to that of compound 1. Analog 50 exhibited an apparent potency in the AF-2 binding assay 300 times that of compound 1.

  在我们发现噻二唑1与胃肠道线虫（例如猪scar虫）的AF-2神经肽受体的强结合后，我们制备了两个系列的类似物。仅含有噻二唑环的系列具有与化合物1相当的效能。类似物50在AF-2结合试验中表现出明显的效能，是化合物1的300倍。
• Method of use, composition, and compounds
  申请人：The Upjohn Company

  公开号：US04017540A1

  公开（公告）日：1977-04-12

  Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive. A new class of pentahalobenzoyl chloride phenylhydrazones is described, particularly pentafluorobenzoyl chloride phenylhydrazones. A further new class of alkylbenzoyl chloride phenylhydrazones, particularly p-toluoyl chloride phenylhydrazones are also described. The compounds are prepared by reacting a benzoic acid phenylhydrazide with phosphorus pentachloride to obtain a benzoyl chloride (dichlorophosphinyl)phenylhydrazone that is reacted with phenol to produce the desired benzoyl chloride phenylhydrazones. Certain of the compounds can be prepared by direct chlorination of a benzaldehyde phenylhydrazone. Methods of use and compositions are described.

  某些苯甲酰氯苯肼已被发现对昆虫和螨类具有活性。苯甲酰环和苯肼酮环可被卤素原子、硝基团或含有1至6个碳原子的烷基取代。描述了一种新类五卤苯甲酰氯苯肼，特别是五氟苯甲酰氯苯肼。还描述了一种新类烷基苯甲酰氯苯肼，特别是对甲酰氯苯肼。这些化合物通过将苯甲酸苯肼与五氯化磷反应制备苯甲酰氯（二氯磷基）苯肼，然后与酚反应制备所需的苯甲酰氯苯肼。其中一些化合物可通过对苯甲醛苯肼直接进行氯化制备。描述了使用方法和组成物。
• Synthesis and Characterization of New 3^″,5^″-DIARYL-3^″<i>H</i>-Dispiropyran/Thiopyran[4,2′-Chroman-3′,2^″-[1,3,4-Thiadiazol]-4′-One Derivatives and Related Compounds as Anticancer and Antiviral Agents
  作者：Mohamed I. Hegab、Eman. M. H. Morsy、Ahmed E. Abd El-Megeid、Mamdouh M. Ali、W. M. El-Senousy、Hala E. M. Tolan、Farouk A. Gad、Farouk M. E. Abdel-Megeid

  DOI：10.1080/10426507.2015.1032410

  日期：2015.11.2

  inhibiting of human tyrosine kinase showed that most of the tested compounds possess antiproliferative activity as potent to moderate growth inhibitory activity, especially compounds 3b, 5a, 5c, 5e, 5g, and 5k. Also, the prepared compounds were tested against rotavirus Wa strain and adenovirus type 7 and the results showed that two compounds (5e,n) were active.

  图形摘要 摘要 一系列 3",5"-二芳基-3"H-二螺吡喃/噻喃[4,2'-色满-3',2"-[1,3,4-噻二唑]-4'-酮 5a -n 由三螺[四氢吡喃(四氢噻喃)-4,5'-2H-色基-[3,4-e][1,3,4]氧二噻吩-2',3"-色满-2"反应合成4'''-四氢吡喃-(四氢噻喃)]-4''-ones 3a,b与腈亚胺(通过相应腙酰氯的三乙胺脱卤化氢原位生成)。化合物 5a 的单晶衍射增加了对已建立结构的支持。通过抑制人酪氨酸激酶对人乳腺癌MCF-7细胞系进行抗癌评价的结果表明，大多数被测化合物具有抗增殖活性，如有效的中度生长抑制活性，尤其是化合物3b、5a、5c、5e、5g ，和 5k。还，
• DE2146192
  申请人：——

  公开号：——

  公开（公告）日：——