propyl 2,3,4-trihydroxybenzoate | 24599-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: propyl 2,3,4-trihydroxybenzoate
• 英文别名: Trihydroxy benzoic acid propyl ester
• CAS: 24599-56-2
• 化学式: C₁₀H₁₂O₅
• 分子量: 212.202
• InChiKey: BXOLUNAZMVQZQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  propyl 2,3,4-trihydroxybenzoate 在 2,6-二甲基吡啶 、 potassium carbonate 作用下， 以 乙醇 、 丁酮 为溶剂， 生成 4-{3-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-8-ylsulfanyl]-2-hydroxy-propoxy}-2,3-dihydroxy-benzoic acid propyl ester
  参考文献：
  名称：

  8-Substituted purine derivatives: a new class of lipid-lowering agents

  摘要：

  A series of purine derivatives have been prepared and their in vivo abilities to lower plasma total cholesterol and triglyceride levels, and to elevate high density lipoprotein (HDL) cholesterol levels in hyperlipemic rats have been tested. Some compounds, among which 8-{2-(R)-hydroxy-3-[(p-isobutoxycarbonyl)phenoxy]propylthio}adenosine 31, 8-{3-[(p-isobutoxy carbonyl)phenoxy]-2-oxopropylthio} adenosine 33 and 8-{3-[(p-isobutoxycarbonyl)phenoxy]-2-hydrazonecarboxamidepropylthio} adenosine 36 appear to be the most interesting, have been found to have both the desired profile of activity and no hepatotoxicity, when administered po at 50, 100 or 300 mg/kg. Compounds 31, 33 and 36, orally tested at the same doses in the 15-d test, lower triglyceride and VLDL/LDL (very low density lipoprotein/low density lipoprotein) cholesterol levels by 10-33% and 13-46%, respectively, and increase HDL-associated cholesterol levels by 10-32%. These molecules have been chosen for further pharmacological and toxicological evaluations.

  DOI：

  10.1016/0223-5234(94)90098-1

文献信息

• USE OF HYDROXYBENZOIC ACIDS AND THEIR ESTERS AND ANALOGUES FOR PREVENTING OR TREATING VIRUS INFECTION
  申请人：QIN Weihua

  公开号：US20080119550A1

  公开（公告）日：2008-05-22

  This invention provides hydroxybenzoic acids, their esters and analogues thereof that are useful for the prevention and/or treatment of virus infection such as HBV, papillomavirus and/or herpes virus infection.

  这项发明提供了对预防和/或治疗病毒感染（如乙型肝炎病毒、乳头状瘤病毒和/或疱疹病毒感染）有用的羟基苯甲酸、其酯和类似物。
• High skin friction cosmetic creams containing dispersed zinc oxide particles as inorganic sunscreen
  申请人：Verma Ritu

  公开号：US20050042187A1

  公开（公告）日：2005-02-24

  A high skin friction cosmetic composition that can provide the consumer-desired sensory properties of traditional vanishing creams, containing solid asymmetric particles and ZnO incorporated by an inventive process. According to the inventive process the temperature during the mixing of ZnO and asymmetric particles is controlled at less than 80° C. and the time of mixing is limited to about 10 minutes. After about 10 minutes, the reaction is quenched by cooling to about 50° C.

  一种高摩擦皮肤美容组合物，可以提供消费者所需的传统消失霜的感官特性，其中包含通过一种创新工艺结合的固体非对称颗粒和ZnO。根据这种创新工艺，在混合ZnO和非对称颗粒的过程中，温度控制在80℃以下，并将混合时间限制在约10分钟左右。大约10分钟后，通过降温至约50℃来停止反应。
• Silicone foams
  申请人：Dow Corning France S.A.

  公开号：EP0506241A1

  公开（公告）日：1992-09-30

  A multi-component foamable silicone composition is described and claimed which is capable of curing quickly at 20°C to provide a low density foamed mass. The composition comprises (A) one or more polydiorganosiloxanes having not less than three alkyl-hydrogensiloxane units per molecule, (B) one or more polydiorganosiloxanes having not less than two alkenyl-siloxane units (C) a liquid alcohol, (D) a fluorinated silicone foam stabilizing material and (E) a platinum catalyst for promoting reaction between the components. The composition may be packaged as two or more individually stable parts of substantially equal volume and viscosity each in a receptacle of material which is adapted to be opened by rupture so as to release the components for admixture. The composition is intended for use in forming a foam medical dressing by dispensing onto a surface e.g. an open wound and allowing the composition to cure at room temperature.

  本发明描述并声称了一种多组分可发泡硅酮组合物，该组合物能够在 20°C 下快速固化，形成低密度发泡物质。该组合物包括：(A) 一种或多种聚二有机硅氧烷，每分子具有不少于三个烷基-氢硅氧烷单元；(B) 一种或多种聚二有机硅氧烷，每分子具有不少于两个烯基-硅氧烷单元；(C) 液体醇；(D) 氟化硅泡沫稳定材料；(E) 铂催化剂，用于促进各组分之间的反应。该组合物可以包装成两个或两个以上体积和粘度基本相等的独立稳定部分，每个部分都装在一个容器中，该容器的材料可以通过破裂打开，从而释放出各组分进行混合。该组合物用于形成泡沫医用敷料，方法是将其分配到表面（如开放性伤口）上，并使组合物在室温下固化。
• TRANSPARENT CONDUCTIVE SHEET FOR TOUCH PANEL, METHOD FOR MANUFACTURING SAME AND TOUCH PANEL
  申请人：SHIN-ETSU POLYMER CO., LTD.

  公开号：EP1947655A1

  公开（公告）日：2008-07-23

  A transparent conductive sheet for a touch panel that has a surface resistivity of not more than 1,000 Ω, a total light transmittance of not less than 80%, and a haze of not more than 5%, and exhibits excellent levels of water resistance and adhesion between a transparent substrate and a transparent conductive layer. The transparent conductive sheet for a touch panel of the present invention includes a transparent substrate and a transparent conductive layer formed on top of the transparent substrate, wherein the transparent conductive layer contains a π-conjugated conductive polymer, a polyanion and an ester compound or specific polymerizable compound. The transparent conductive layer may also include conductivity improvers, dopants, other resin components and/or additives as required. A conductivity improver is preferably included to improve the conductivity.

  一种用于触控板的透明导电片，其表面电阻率不大于 1,000 Ω，总透光率不小于 80%，雾度不大于 5%，并且在透明基板和透明导电层之间具有优异的防水性和附着力。本发明的触控板用透明导电片包括透明基板和在透明基板上形成的透明导电层，其中透明导电层包含π-共轭导电聚合物、聚阴离子和酯类化合物或特定的可聚合化合物。透明导电层还可根据需要包含导电性改进剂、掺杂剂、其他树脂成分和/或添加剂。最好加入导电性改进剂以提高导电性。
• Transport conductive sheet for a touch panel, method for manufacturing transparent conductive sheet for a touch panel and a touch panel
  申请人：SHIN-ETSU POLYMER CO., LTD.

  公开号：EP2109117A1

  公开（公告）日：2009-10-14

  A transparent conductive sheet for a touch panel, comprising a transparent substrate and a transparent conductive layer formed on top of said transparent substrate, wherein said transparent conductive layer comprises a π-conjugated conductive polymer, a polyanion, and a polymerizable compound, wherein said polymerizable compound is (a) and (b), or only (b), and (a): a compound containing a glycidyl group, (b): a compound containing a hydroxyl group, and one group selected from the group consisting of an allyl group, vinyl ether group, methacryl group, acryl group, methacrylamide group and acrylamide group.

  一种用于触控板的透明导电片材，包括透明基板和在所述透明基板上形成的透明导电层，其中所述透明导电层包括π-共轭导电聚合物、聚阴离子和可聚合化合物，其中所述可聚合化合物为(a)和(b)，或仅为(b)，以及 (a) 含缩水甘油基的化合物、 (b): 含羟基的化合物，以及一个选自由烯丙基、乙烯基醚基、甲基丙烯基、丙烯基、 甲基丙烯酰胺基和丙烯酰胺基组成的基团。