苯甲酰胺基脲 | 2845-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲酰胺基脲
• 英文名称: 1-benzoyl semicarbazide
• 英文别名: benzoylsemicarbazide；1-Benzoyl-semicarbazid；N-Benzoyl-hydrazin-N'-carbonsaeureamid；N¹-Benzoyl-semicarbazid；Benzoesaeure-semicarbazid；4-Benzoylsemicarbazid；2-Benzoylhydrazinecarboxamide；benzamidourea
• CAS: 2845-79-6
• 化学式: C₈H₉N₃O₂
• 分子量: 179.178
• InChiKey: HUZZTWCBDUFIOU-UHFFFAOYSA-N

物化性质

• 熔点：
  215 °C
• 密度：
  1.285±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  苯甲酰胺基脲 在 三氯氧磷 作用下， 生成 5-苯基-2-氨基-1,3,4-噁二唑
  参考文献：
  名称：

  Gehlen,H.; Moeckel,K., Justus Liebigs Annalen der Chemie, 1962, vol. 660, p. 144 - 147

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-二苯甲酰氨基甲酰肼 在 sodium hydroxide 作用下， 生成 苯甲酰胺基脲
  参考文献：
  名称：

  Nakai et al., Pharmaceutical Bulletin, 1957, vol. 5, p. 576,578

  摘要：

  DOI：

文献信息

• Facile Access to a Variety of 2,5-Biaryl-1,2,4-triazol-3-ones via Regioselective N-Arylation of Triazolones
  作者：Ji-Yeon Park、Jung-Hyun Chae

  DOI：10.5012/bkcs.2010.31.8.2143

  日期：2010.8.20

  A selective synthetic method of the 2,5-biaryltriazolones has been developed via copper-catalyzed N-arylation reaction. Aryltriazolones, which were readily prepared from commercially available compounds, were N-arylated to 2,5-biaryltriazolones with high regioselectivity. This approach allows for access to a variety of 2,5-biaryl-1,2,4-trizol-3-ones in a simple and practical manner.

  已开发了一种选择性合成2,5-双芳基三唑酮的方法，采用了铜催化的N-芳基化反应。芳基三唑酮可以从商用化合物中便捷制备，并以高区域选择性被N-芳基化为2,5-双芳基三唑酮。这种方法以简单和实用的方式提供了各种2,5-双芳基-1,2,4-三唑-3-酮的合成途径。
• [EN] NOVEL 3-SUBSTITUTED-1,4-BENZODIAZEPINES<br/>[FR] NOUVELLES 1,4-BENZODIAZEPINES 3-SUBSTITUEES
  申请人：UNIV ASTON

  公开号：WO2004106310A1

  公开（公告）日：2004-12-09

  The present invention relates to compounds of formula (I). The invention also relates to methods for preparing the compounds and their uses as CCK receptor ligands and CCK antagonists.

  本发明涉及式（I）的化合物。该发明还涉及制备这些化合物的方法，以及它们作为CCK受体配体和CCK拮抗剂的用途。
• 3-Aryl-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof
  申请人：Cai Xiong Sui

  公开号：US20080113984A1

  公开（公告）日：2008-05-15

  Disclosed are 3-aryl-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and related compounds thereof, represented by the Formula I: wherein Ar 1 , Ar 2 , and X are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及公开的3-芳基-6-芳基-7H-[1,2,4]三唑并[3,4-b][1,3,4]噻二唑及其相关化合物，其由公式I表示：其中Ar1、Ar2和X在此定义。本发明涉及发现具有公式I的化合物是caspase激活剂和凋亡诱导剂。因此，本发明的caspase激活剂和凋亡诱导剂可用于诱导在各种临床情况下发生异常细胞的无控制生长和扩散的细胞死亡。
• Rubber composition and pneumatic tires
  申请人：Bridgestone Corporation

  公开号：US06380288B1

  公开（公告）日：2002-04-30

  A rubber composition prepared by compounding 0.05 to 20 parts by weight of at least one selected from substituted hydrazide compounds represented by the following Formulas (I) to (IV) per 100 parts by weight of a rubber component comprising at least one rubber selected from the group consisting of natural rubber and synthetic rubber, and a pneumatic tire using the same: wherein A represents one selected from the group consisting of an aromatic group which may have a substituent, a hydantoin ring which may have a substituent, and a saturated or unsaturated linear hydrocarbon having 1 to 18 carbon atoms; Y represents hydrogen, an amino group, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group, an aromatic group, a pyridyl group or hydrazino group; and R1 to R11 each represent hydrogen, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group or an aromatic group.

  一种橡胶组合物，其通过将以下式子（I）到（IV）中的至少一种取代肼化合物的0.05至20重量份与至少一种天然橡胶或合成橡胶组成的橡胶组分的100重量份混合制备而成，其中A表示选自芳香族基团，该基团可能带有取代基，咪唑环，该环可能带有取代基，以及具有1至18个碳原子的饱和或不饱和线性碳氢化合物中的一种；Y表示氢，氨基，具有1至18个碳原子的烷基，环烷基，烯基，芳香族基团，吡啶基或肼基；R1到R11分别表示氢，具有1至18个碳原子的烷基，环烷基或芳香族基团。并且使用该橡胶组合物制备的气动轮胎。
• Preparation for promoting hair growth
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0540854A2

  公开（公告）日：1993-05-12

  A preparation for promoting hair growth is disclosed, which contains as an effective ingredient or ingredients one or more compounds selected from the group consisting of purine compounds, pyridylurea compounds, diphenylurea compounds, pyrimidine compounds, imidazole compounds, benzoylaminourea compounds and 4- substituted aminopyrrolo[2,3-d]pyrimidine compounds. This preparation exhibits an excellent effect of promoting hair growth or curing alopecia such as male alopecia or alopecia areata. Of the effective compounds, purine compounds and pyridyl compounds exhibit particularly remarkable effects.

  本发明公开了一种促进毛发生长的制剂，其有效成分包含一种或多种选自以下组别的化合物：嘌呤化合物、吡啶脲化合物、二苯基脲化合物、嘧啶化合物、咪唑化合物、苯甲酰氨基脲化合物和 4-取代氨基吡咯并[2,3-d]嘧啶化合物。该制剂在促进毛发生长或治疗脱发（如男性脱发或斑秃）方面效果显著。在有效化合物中，嘌呤化合物和吡啶化合物的效果尤为显著。