N-(2-氯苯基)-7H-嘌呤-6-胺 | 6296-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: N-(2-氯苯基)-7H-嘌呤-6-胺
• 英文名称: N⁶-(2-Chlorophenyl)adenine
• 英文别名: 6-(2-chloroanilino)purine；(2-Chloro-phenyl)-(9H-purin-6-yl)-amine；N-(2-chlorophenyl)-7H-purin-6-amine
• CAS: 6296-90-8
• 化学式: C₁₁H₈ClN₅
• 分子量: 245.671
• InChiKey: QZPHGMKICYKDIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-deoxy-D-ribose 、 N-(2-氯苯基)-7H-嘌呤-6-胺 在 四磷十氧化物 、 (C₄H₉)3N 、 水 作用下， 生成 (3S,3'S,4R,4'R,6R,6'R)-6,6'-azanediylbis(4-(6-((2-chlorophenyl)amino)-9H-purin-9-yl)tetrahydro-2H-pyran-3-ol)
  参考文献：
  名称：

  Andersen, Jesper; Pedersen, Erik B., Liebigs Annalen der Chemie, 1986, # 11, p. 1837 - 1846

  摘要：

  DOI：
• 作为产物：
  描述：

  邻氯苯胺 、 6-氯嘌呤 以 2,4-滴二甲胺盐 为溶剂， 反应 12.0h， 生成 N-(2-氯苯基)-7H-嘌呤-6-胺
  参考文献：
  名称：

  Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases

  摘要：

  本文描述了用于调节激酶活性的化合物和组合物，以及使用这些化合物和组合物调节激酶活性的方法。本文还描述了在治疗和预防受试者中各种疾病和不良状况中使用这些化合物和/或组合物的方法。

  公开号：

  US20050153989A1

文献信息

• Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
  申请人：CHEN Han-Min

  公开号：US20140303112A1

  公开（公告）日：2014-10-09

  The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.

  本发明涉及一种治疗疾病或病情的方法，该疾病或病情容易通过AMPK激活剂和公式化合物得到改善，这些化合物有助于激活AMP激活蛋白激酶（AMPK），并将这些化合物用于预防或治疗疾病，包括糖尿病前期、2型糖尿病、X综合症、代谢综合征和肥胖症。
• Heterocyclic compound based on n6-substituted adenine, methods, of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
  申请人：Dolezal Karel

  公开号：US20050043328A1

  公开（公告）日：2005-02-24

  New heterocyclic derivatives based on N 6 -substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

  基于N6-取代腺嘌呤的新杂环衍生物具有抗癌、有丝分裂、免疫抑制和抗衰老的性质，适用于植物、动物和人类细胞，并提供其制备方法。还包括含有这些衍生物作为活性化合物的药物组合物、化妆品制剂和生长调节剂，以及这些衍生物用于制备药物、化妆品制剂、生物技术过程、化妆品和农业的用途。
• HETEROCYCLIC COMPOUNDS BASED ON N6-SUBSTITUTED ADENINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS
  申请人：Popa Igor

  公开号：US20080014227A1

  公开（公告）日：2008-01-17

  Novel heterocyclic derivatives based on N 6 -substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

  基于N6-取代腺嘌呤的新型杂环衍生物，具有抗癌、有丝分裂、免疫抑制和抗衰老的性质，适用于植物、动物和人类细胞，以及它们的制备方法。还包括含有这些衍生物作为活性化合物的制药组合物、化妆品制剂和生长调节剂，以及使用这些衍生物制备药物、化妆品制剂、生物技术过程、化妆品和农业的方法。
• Phosphorus Pentoxide in Organic Synthesis; II¹. A New, One-Step Conversion of Hypoxanthine into<i>N</i> ⁶-Substituted Adenines
  作者：Nabih S. Girgis、Erik B. Pedersen

  DOI：10.1055/s-1982-29845

  日期：——
• HETEROCYCLIC COMPOUND BASED ON N sp 6 /sp &minus;SUBSTITUTED ADENINE&comma; METHODS OF THEIR PREPARATION&comma; THEIR USE FOR PREPARATION OF DRUGS&comma; COSMETIC PREPARATIONS AND GROWTH REGULATORS&comma; PHARMACEUTICAL PREPARATIONS&comma; COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE
  申请人：Ustav Experimentalni Botaniky Akademie ved Ceské Republiky

  公开号：EP1419157A2

  公开（公告）日：2004-05-19