(Z)-2-formyl-3-phenylacrylonitrile | 56069-64-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: (Z)-2-formyl-3-phenylacrylonitrile
• 英文别名: 2-formyl-3t-phenyl-acrylonitrile；(Z)-2-formyl-3-phenylprop-2-enenitrile
• CAS: 56069-64-8
• 化学式: C₁₀H₇NO
• 分子量: 157.172
• InChiKey: MIKUEHDPEIQKCU-POHAHGRESA-N

物化性质

• 熔点：
  99-100 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 沸点：
  60-75 °C
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙烯,四甲氧基- 、 (Z)-2-formyl-3-phenylacrylonitrile 以91%的产率得到
  参考文献：
  名称：

  OOMS P. H. J.; SCHEEREN J. W.; NIVARD R. J. F., SYNTHESIS , 1975, NO 4, 260-262

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲醛 、 丙烯腈 在 氢氧化钾 作用下， 生成 (Z)-2-formyl-3-phenylacrylonitrile
  参考文献：
  名称：

  The Reaction of Acrylonitrile with Benzaldehyde under Cyanoethylation Conditions

  摘要：

  DOI：

  10.1021/ja01593a044

文献信息

• Substituted bicyclic pyrimidine compounds with tubulin and multiple receptor inhibition
  申请人：Duquesne University of the Holy Spirit

  公开号：US10906910B2

  公开（公告）日：2021-02-02

  This invention provides substituted bicyclic pyrimidine compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of H and a straight or branched chain alkyl group having from 1 to 10 carbon atoms, wherein the alkyl group is partially or completely saturated, each having tubulin and multiple receptor inhibition properties. Methods of treating a patient diagnosed with cancer are disclosed comprising administering to the patient a therapeutically effective amount of the substituted bicyclic pyrimidine compounds, or a pharmaceutically acceptable salt thereof.

  本发明提供了下式的取代双环嘧啶化合物： 或其药学上可接受的盐，其中 R 选自由 H 和具有 1 至 10 个碳原子的直链或支链烷基组成的组，其中烷基部分或完全饱和，每种化合物都具有抑制小管蛋白和多种受体的特性。本发明公开了治疗诊断为癌症的患者的方法，包括向患者施用治疗有效量的取代双环嘧啶化合物或其药学上可接受的盐。
• Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides
  作者：Kimberley J. Powell、Li-Chen Han、Pallavi Sharma、John E. Moses

  DOI：10.1021/ol500618w

  日期：2014.4.18

  A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.
• SUBSTITUTED BICYCLIC PYRIMIDINE COMPOUNDS WITH TUBULIN AND MULTIPLE RECEPTOR INHIBITION
  申请人：Duquesne University of the Holy Spirit

  公开号：EP3125899B1

  公开（公告）日：2019-10-02
• COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER
  申请人：Jegou Gwenaëlle

  公开号：US20100172858A1

  公开（公告）日：2010-07-08

  One subject of the present invention is a cosmetic composition for treating keratinous fibres, in particular human keratinous fibres such as the hair, which comprises at least one polymer obtained from dielectrophilic monomers. The composition of the invention makes it possible to give the hair body, bulk or volume in a long-lasting fashion. Another subject of the invention is use of the cosmetic composition for treating keratinous fibres, especially conditioning and/or dyeing keratinous fibres.
• Substituted Bicyclic Pyrimidine Compounds with Tubulin and Multiple Receptor Inhibition
  申请人：Duquesne University of the Holy Spirit

  公开号：US20190300538A1

  公开（公告）日：2019-10-03

  This invention provides substituted bicyclic pyrimidine compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of H and a straight or branched chain alkyl group having from 1 to 10 carbon atoms, wherein the alkyl group is partially or completely saturated, each having tubulin and multiple receptor inhibition properties. Methods of treating a patient diagnosed with cancer are disclosed comprising administering to the patient a therapeutically effective amount of the substituted bicyclic pyrimidine compounds, or a pharmaceutically acceptable salt thereof.