2-fluorobenzylphosphonic acid | 80395-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluorobenzylphosphonic acid
• 英文别名: Phosphonic acid, [(2-fluorophenyl)methyl]-；(2-fluorophenyl)methylphosphonic acid
• CAS: 80395-15-9
• 化学式: C₇H₈FO₃P
• 分子量: 190.111
• InChiKey: KNZXJOCOROFSOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-fluorobenzylphosphonic acid 在 三氧化硫 作用下， 反应 240.0h， 生成 2-fluorobenzylphosphono-3,5-disulphonic acid
  参考文献：
  名称：

  Montoneri, E.; Savarino, P.; Adani, F., Phosphorus, Sulfur and Silicon and the Related Elements, 1995, vol. 106, # 1, p. 37 - 46

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氟苄基膦酸二乙酯 在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到2-fluorobenzylphosphonic acid
  参考文献：
  名称：

  Steric Control over the Threading of Pyrophosphonates with One or Two Cyanostar Macrocycles during Pseudorotaxane Formation

  摘要：

  摘要阴离子的超分子识别越来越多地被用于实现超分子结构的自组装，从笼状结构、聚合物到（伪）轮烷。此前已有研究表明，氰星（CS）大环与有机磷酸酯形成 2 ：1 的复合物，这些复合物可以通过堵塞变成 [3]rotaxanes 。在这里，我们首次实现了对由蓝星大环和基于有机-焦磷酸盐的线组成的假轮烷组装的立体控制。螺纹上立体体积的细微差别使得[3]赝轴烷或[2]赝轴烷得以形成。我们证明，穿线动力学受有机-焦磷酸盐的立体需求支配，在一种情况下，穿线速度会减慢到几分钟。计算结果表明，二离子在大环内部发生了立体偏移。我们的发现拓宽了青柱-阴离子组装的范围，并可能对设计其方向性是相对缓慢滑动结果的分子机器有意义。

  DOI：

  10.1002/chem.202300899

文献信息

• [EN] CYCLIC AMINE COMPOUNDS AS CCR5 ANTAGONISTS<br/>[FR] COMPOSES D'AMINE CYCLIQUE UTILISES COMME ANTAGONISTES DE CCR5
  申请人：TAKEDA CHEMICAL INDUSTRIES LTD

  公开号：WO2001025200A1

  公开（公告）日：2001-04-12

  A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R?1 and R2¿ may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N?+-R5 •Y-(R5¿ is a hydrocarbon group; Y- is a counter anion); R3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1 is a bond, CO or SO¿2; G?2 is CO, SO¿2?, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3 aliphatic hydrocarbon which may be substituted; provided that J is methine when G2 is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G?1¿ is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

  化合物式为（I）（其中R1是氢原子，可被取代的碳氢基团，可被取代的非芳香杂环基团，R2是可被取代的碳氢基团，可被取代的非芳香杂环基团，或R1和R2可以与A一起结合形成可被取代的杂环基团；A是N或N+ -R5 • Y-（R5是碳氢基团；Y-是反离子）；R3是可被取代的环烃基团或可被取代的杂环基团；n为0或1；R4是氢原子，可被取代的碳氢基团，可被取代的杂环基团，可被取代的烷氧基，可被取代的芳氧基，或可被取代的氨基，E是可被除氧基以外的基取代的二价脂肪烃基团；G1是键，CO或SO2；G2是CO，SO2，NHCO，CONH或OCO；J是甲基或氮原子；Q和R中的每一个都是一个键或一个可被取代的二价C1-3脂肪基团；前提是当G2是OCO时，J是甲基，当另一个是键时，其中一个不是键，当G1是键时，Q和R中的每一个都没有被氧基团取代）或其盐具有强效的CCR5拮抗活性，并可用于人类各种HIV感染疾病（例如艾滋病）的治疗或预防。
• Substituted imidazole compound and use thereof
  申请人：Kuroita Takanobu

  公开号：US20090227560A1

  公开（公告）日：2009-09-10

  The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

  本发明涉及一种由以下式表示的化合物：其中每个符号如描述中所定义，或其盐或前药。本发明的化合物具有优越的肾素抑制活性，因此可用作预防或治疗高血压、由高血压引起的各种器官损伤等的药物。
• POLYMER ELECTROLYTE COMPOSITION AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTROLYTE ASSEMBLY, AND SOLID POLYMER FUEL CELL USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3131145A1

  公开（公告）日：2017-02-15

  [Problem] To provide: a polymer electrolyte composition that has excellent chemical stability that makes it possible to withstand a strong oxidizing atmosphere during fuel cell operation, that makes it possible to achieve excellent protonic conductivity under low humidity conditions, excellent mechanical strength, and excellent physical durability, and that is highly practical; and a polymer electrolyte membrane, a membrane-electrode assembly, and a solid polymer fuel cell that use the polymer electrolyte composition. [Solution] A polymer electrolyte composition that comprises at least an ionic group-containing polymer (A), an organic phosphorus-based additive (C), and a nitrogen-containing heteroaromatic ring system additive (D) and that is characterized by the nitrogen-containing heteroaromatic ring system additive (D) comprising at least three nitrogen-containing heteroaromatic rings within a molecule thereof. In addition, the polymer electrolyte membrane, the catalyst layer-equipped electrolyte membrane, the membrane-electrode assembly, and the solid polymer fuel cell of the present invention are characterized by being configured using the polymer electrolyte composition.

  问题 提供一种聚合物电解质组合物，该组合物具有优异的化学稳定性，能够在燃料电池运行期间耐受强氧化性气氛，能够在低湿度条件下实现优异的质子电导率，具有优异的机械强度和优异的物理耐久性，并且具有很高的实用性；以及一种使用该聚合物电解质组合物的聚合物电解质膜、膜电极组件和固体聚合物燃料电池。[解决方案]一种聚合物电解质组合物，它至少包含一种含离子基团的聚合物（A）、一种有机磷基添加剂（C）和一种含氮杂芳香族环系添加剂（D），其特征在于含氮杂芳香族环系添加剂（D）在其分子内至少包含三个含氮杂芳香族环。此外，本发明的聚合物电解质膜、配备催化剂层的电解质膜、膜电极组件和固体聚合物燃料电池的特征在于使用聚合物电解质组合物进行配置。
• Physically reconfigurable structurally embedded vascular antenna
  申请人：Government of the United States, as represented by the Secretary of the Air Force

  公开号：US10944178B1

  公开（公告）日：2021-03-09

  A reconfigurable antenna comprises a panel having a liquid metal pump coupled to a power supply; a liquid metal reservoir in fluid communication with the pump; one or more channels for transporting the liquid metal, each of the one or more channels having a proximal end in fluid communication with the pump, each of the one or more channels having a vent at a distal end, wherein application of power to the pump moves the liquid metal into or out of the channels thereby reconfiguring the antenna. The pump may be a pneumatic pump or a magnetohydrodynamic pump, and a layer of a phosphonic acid may be included on the liquid metal-bearing surfaces of the channels. The phosphonic acid may be decylphosphonic acid (DPA), fluorobenzylphosphonic acid (FPA), or difluorobenzylphosphonic acid (DFPA), and one or more sensors may be coupled to the panel for determining the position of the liquid metal in the channels.

  一种可重新配置的天线包括一个面板，面板上有一个与电源相连的液态金属泵；一个与泵流体相通的液态金属贮槽；一个或多个用于输送液态金属的通道，一个或多个通道中的每个通道都有一个与泵流体相通的近端，一个或多个通道中的每个通道的远端都有一个通风口，其中向泵供电可使液态金属进入或流出通道，从而重新配置天线。泵可以是气动泵或磁流体泵，通道的液态金属承载表面可以包括一层膦酸。膦酸可以是癸基膦酸 (DPA)、氟苄基膦酸 (FPA) 或二氟苄基膦酸 (DFPA)，一个或多个传感器可以连接到面板上，用于确定通道中液态金属的位置。
• Physically reconfigurable structurally embedded vascular antenna and method of making
  申请人：Government of the United States, as represented by the Secretary of the Air Force

  公开号：US10985446B1

  公开（公告）日：2021-04-20

  A method of making a reconfigurable antenna comprises the steps of applying one or more first layers of a prepreg laminate fabric to a form having a desired contour; applying a pattern corresponding to an antenna shape to the first layers of prepreg fabric; applying one or more second layers of the prepreg laminate fabric atop the pattern to form a laminate stack; curing the laminate stack; and removing the pattern to form channels in the antenna shape. The desired contour may be an aircraft skin panel or an airfoil panel. The pattern may be a polymer sheet with an applied cPLA antenna design. The curing step may be performed in a vacuum bag under the application of vacuum and heat. The removing step may be performed by heating the cured laminate stack to remove the pattern.

  一种制造可重新配置天线的方法包括以下步骤：将一层或多层预浸料层压织物涂抹在具有所需轮廓的形状上；将与天线形状相对应的图案涂抹在第一层预浸料织物上；在图案上涂抹一层或多层第二层预浸料层压织物以形成层压叠层；固化层压叠层；以及去除图案以在天线形状中形成通道。所需的轮廓可以是飞机蒙皮面板或机翼面板。图案可以是带有应用 cPLA 天线设计的聚合物薄片。固化步骤可在真空袋中通过真空和加热进行。移除步骤可通过加热固化的层压板来移除图案。