4-Chloro-N-{3-chloro-4-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-trifluoromethyl-benzamide | 1192309-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chloro-N-{3-chloro-4-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-trifluoromethyl-benzamide
• 英文别名: 4-Chloro-n-(3-chloro-4-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide；4-chloro-N-[3-chloro-4-[2-[2-(dimethylamino)ethylamino]-8-methoxy-7-oxopyrido[2,3-d]pyrimidin-6-yl]phenyl]-3-(trifluoromethyl)benzamide
• CAS: 1192309-54-8
• 化学式: C₂₆H₂₃Cl₂F₃N₆O₃
• 分子量: 595.408
• InChiKey: YQIAPRMERYJPMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  99.7
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  6-(4-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one 、 3-三氟甲基-4-氯苯甲酸 在 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85%的产率得到4-Chloro-N-{3-chloro-4-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-trifluoromethyl-benzamide
  参考文献：
  名称：

  Improved raf inhibitors

  摘要：

  公开号：

  EP2112150B1

文献信息

• RAF INHIBITORS
  申请人：BACKES Alexander

  公开号：US20110257207A1

  公开（公告）日：2011-10-20

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

  本发明提供了吡啶并[2,3-d]嘧啶-7-酮的衍生物。这些化合物是Raf等激酶的抑制剂，包括表现出抗增殖活性的化合物，包括对肿瘤细胞的抗活性，并且在治疗癌症等疾病方面是有用的。
• Raf inhibitors
  申请人：Forma Therapeutics, Inc.

  公开号：US08232283B2

  公开（公告）日：2012-07-31

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

  本发明提供了吡啶并[2,3-d]嘧啶-7-酮的衍生物。这些化合物是Raf等激酶的抑制剂，包括表现出抗增殖活性的化合物，包括对肿瘤细胞的抗作用，并可用于治疗包括癌症在内的疾病。
• US8232283B2
  申请人：——

  公开号：US8232283B2

  公开（公告）日：2012-07-31
• [EN] IMPROVED RAF INHIBITORS<br/>[FR] INHIBITEURS DE RAF AMÉLIORÉS
  申请人：GPC BIOTECH AG

  公开号：WO2009130015A1

  公开（公告）日：2009-10-29

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Improved raf inhibitors
  申请人：Forma Therapeutics, Inc.

  公开号：EP2112150B1

  公开（公告）日：2013-10-16