[3-(1-Ethyl-propylamino)-2,4-dihydroxy-phenyl]-phenyl-methanone | 253681-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-(1-Ethyl-propylamino)-2,4-dihydroxy-phenyl]-phenyl-methanone
• 英文别名: {2,4-Dihydroxy-3-[(pentan-3-yl)amino]phenyl}(phenyl)methanone；[2,4-dihydroxy-3-(pentan-3-ylamino)phenyl]-phenylmethanone
• CAS: 253681-42-4
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: OAPIPXZIHDLJLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [3-(1-Ethyl-propylamino)-2,4-dimethoxy-phenyl]-phenyl-methanone 在 三氯化铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 3.0h， 生成 [3-(1-Ethyl-propylamino)-2,4-dihydroxy-phenyl]-phenyl-methanone
  参考文献：
  名称：

  Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

  摘要：

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00504-1

文献信息

• Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro
  作者：Ronan Larget、Brian Lockhart、Bruno Pfeiffer、Anne Neudorffer、Maurice-Bernard Fleury、Martine Largeron

  DOI：10.1016/s0960-894x(99)00504-1

  日期：1999.10

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.