6-(diphenylarsanyl)uracil | 1236194-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(diphenylarsanyl)uracil
• 英文别名: 6-diphenylarsanyl-1H-pyrimidine-2,4-dione
• CAS: 1236194-14-1
• 化学式: C₁₆H₁₃AsN₂O₂
• 分子量: 340.213
• InChiKey: KDJNBXTZNHOJMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.42
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  diphenyl(2,4-dimethoxy-6-pyrimidyl)arsane 在 盐酸 、 水 作用下， 反应 48.0h， 以75%的产率得到6-(diphenylarsanyl)uracil
  参考文献：
  名称：

  Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

  摘要：

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.

  DOI：

  10.1021/jo101064e

文献信息

• Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure
  作者：Javier I. Bardagí、Roberto A. Rossi

  DOI：10.1021/jo101064e

  日期：2010.8.6

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.