Methyl-2.5-dimethyl-3-aminobenzoat | 27023-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl-2.5-dimethyl-3-aminobenzoat
• 英文别名: Methyl 3-amino-2,5-dimethylbenzoate
• CAS: 27023-02-5
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: ZGWJTVNFUJQBHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED BENZENE COMPOUNDS
  申请人：Epizyme Inc

  公开号：EP3165520A1

  公开（公告）日：2017-05-10

  The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and such compounds for use in treating cancer. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及取代苯化合物。本发明还涉及含有这些化合物的药物组合物和用于治疗癌症的此类化合物。本发明还涉及将此类化合物用于研究或其他非治疗目的。
• [EN] ESTROGEN RECEPTOR MODULATORS<br/>[FR] MODULATEURS DE RECEPTEUR D'OESTROGENES
  申请人：MERCK & CO INC

  公开号：WO2004073612A2

  公开（公告）日：2004-09-02

  The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer.