6-ethoxy-2,5-dimethylpyridin-3-amine | 1206802-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-ethoxy-2,5-dimethylpyridin-3-amine
• CAS: 1206802-78-9
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: JATQOUSAUMHLJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-3,5-dichloro-1-(1-cyclopropylethyl)pyrazin-2(1H)-one 、 6-ethoxy-2,5-dimethylpyridin-3-amine 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-5-chloro-1-(1-cyclopropylethyl)-3-(6-ethoxy-2,5-dimethylpyridin-3-ylamino)pyrazin-2(1H)-one
  参考文献：
  名称：

  Synthesis and structure–activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

  摘要：

  A series of N-3-pyridylpyrazinones was investigated as corticotropin-releasing factor-1 receptor antagonists. It was observed that the binding affinity of analogues containing a pyridyl group was influenced not only by the substitution pattern on the pyridyl group, but also by the pK(a) of the pyridyl nitrogen. Analogues containing a novel 6-(difluoromethoxy)-2,5-dimethylpyridin-3-amine group were among the most potent N-3-pyridylpyrazinones synthesized. The synthesis and SAR of N-3-pyridylpyrazinones is described herein. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.129

文献信息

• Substituted Carbamate Derivatives as Modulators of Corticotropin-Releasing Factor Receptor Activity
  申请人：Hartz Richard A.

  公开号：US20110124662A1

  公开（公告）日：2011-05-26

  The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds are CRF receptor antagonists and may be useful for treating disorders associated with abnormal CRF levels or aberrant functioning of CRF receptors.

  本公开提供公式(I)的化合物，包括其盐，以及使用这些化合物的组合物和方法。这些化合物是CRF受体拮抗剂，可能对治疗与异常CRF水平或CRF受体异常功能相关的疾病有用。
• Substituted carbamate derivatives as modulators of corticotropin-releasing factor receptor activity
  申请人：Hartz Richard A.

  公开号：US08436000B2

  公开（公告）日：2013-05-07

  The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds are CRF receptor antagonists and may be useful for treating disorders associated with abnormal CRF levels or aberrant functioning of CRF receptors.

  本公开提供式(I)化合物，包括其盐，以及使用该化合物的组合物和方法。该化合物是CRF受体拮抗剂，可用于治疗与CRF水平异常或CRF受体异常功能相关的疾病。
• SUBSTITUTED CARBAMATE DERIVATIVES AS MODULATORS OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR ACTIVITY
  申请人：Bristol-Myers Squibb Company

  公开号：EP2307024A1

  公开（公告）日：2011-04-13
• US8436000B2
  申请人：——

  公开号：US8436000B2

  公开（公告）日：2013-05-07
• [EN] SUBSTITUTED CARBAMATE DERIVATIVES AS MODULATORS OF CORTICOTROPIN-RELEASING FACTOR RECEPTOR ACTIVITY<br/>[FR] DÉRIVÉS DE CARBAMATE SUBSTITUÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU RÉCEPTEUR DE FACTEUR DE LIBÉRATION DE CORTICOTROPINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010014687A1

  公开（公告）日：2010-02-04

  The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds are CRF receptor antagonists and may be useful for treating disorders associated with abnormal CRF levels or aberrant functioning of CRF receptors.