benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3-butenoate | 91939-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3-butenoate
• 英文别名: benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinone-1-yl)-3-methyl-3-butenate；Benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3butenoate；benzyl 2-[2-(benzenesulfonylsulfanyl)-4-oxo-3-[(2-phenoxyacetyl)amino]azetidin-1-yl]-3-methylbut-3-enoate
• CAS: 91939-45-6
• 化学式: C₂₉H₂₈N₂O₇S₂
• 分子量: 580.683
• InChiKey: KYXQKIALYRFNRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3-butenoate 在 氯 、 碳酸氢钠 作用下， 以 四氯化碳 、 benzenedioxane 为溶剂， 以98%的产率得到benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinone-1-yl)-3-chloromethyl-3-butenate
  参考文献：
  名称：

  Halogenation process for preparing

  摘要：

  一种制备式（I）的氮杂环丙酮衍生物的方法，其中R1代表芳基、芳基甲基基或芳基氧甲基基，R2代表氢原子或羧基保护基，R3代表烷基或芳基，该方法包括将式（II）的氮杂环丙酮衍生物与氯化试剂反应，其中式（II）中R1、R2和R3如上所定义。

  公开号：

  US04789740A1
• 作为产物：
  描述：

  Benzyl alpha-[3-phenoxymethyl-7-oxo-4-thia-2,6-diazabicyclo[3,2,0]hept-2-en-6-yl]-alpha-isopropenylacetate 、 苯磺酰溴 生成 benzyl 2-(3-phenoxyacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3-butenoate
  参考文献：
  名称：

  TORII, SIGERU;TANAKA, HIDEO;SHIROI, TAKASHI;SASAOKA, MICHIO;SAITO, NORIO;+

  摘要：

  DOI：

文献信息

• Process for preparation of azetidinone derivatives
  申请人：Otsuka Kagaku Kabushiki Kaisha

  公开号：US04713452A1

  公开（公告）日：1987-12-15

  A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formula R.sup.3 SO.sub.2 CN (VII) wherein R.sup.3 is defined above.

  一种制备式为##STR1##的氮杂环丙酮衍生物的方法，其中R.sup.1为氢、卤素或低级烷氧基，R.sup.2为氢、卤素、低级烷氧基、氨基或者##STR2##（其中R.sup.5为取代或未取代苯基、取代或未取代苯甲基、取代或未取代苯氧甲基或者取代或未取代苯甲酰基），或者当R.sup.1和R.sup.2结合在一起时为羰基，R.sup.3为取代或未取代苯基，R.sup.4为氢、可选取代的碳氢残基或者来自无机酸或有机酸的酰基、硅基、磺酰基或者磷酸酯基，该方法包括将式为##STR3##的二硫杂环丙酮衍生物与式为R.sup.3 SO.sub.2 CN (VII)的化合物（其中R.sup.3如上所定义）反应。
• Process for preparation of 4-sulfonylthio azetidinone derivatives
  申请人：Otsuka Kagaku Kabushiki Kaisha

  公开号：US04740596A1

  公开（公告）日：1988-04-26

  A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formula R.sup.3 SO.sub.2 SR.sup.9 (VII) wherein R.sup.3 and R.sup.9 are as defined above.

  一种制备式为##STR1##的氮杂环丙酮衍生物的方法，其中R.sup.1是氢、卤素或低级烷氧基，R.sup.2是氢、卤素、低级烷氧基、氨基或者一个基团##STR2##（其中R.sup.5是取代或未取代的苯基、取代或未取代的苯甲基、取代或未取代的苯氧甲基或取代或未取代的苯甲酰基），或者当R.sup.1和R.sup.2结合在一起时，它们是羰基，R.sup.3是取代或未取代的苯基，R.sup.4是氢、可选取代的碳氢残基或来自无机酸或有机酸的酰基、硅烷基、磺酰基或膦酸基，所述方法包括将式为##STR3##的二硫杂环丙酮衍生物与式为R.sup.3 SO.sub.2 SR.sup.9 (VII)的化合物反应，其中R.sup.3和R.sup.9如上所定义的取代或未取代的含氮芳杂环残基。
• Process for preparing azetidinone derivatives
  申请人：OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA

  公开号：EP0114729A1

  公开（公告）日：1984-08-01

  A process for preparing an azetidinone derivative represented by the formula (1) wherein R1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted phenylmethyl group or a substituted or unsubstituted phenoxymethyl group, R2 represents a hydrogen atom or a group for protecting carboxylic acid and Ar represents a substituted or unsubstituted phenyl group, the process comprising reacting a thiazolineazetidinone derivative represented by the formula (2) wherein R1 and R2 are as defined above with a sulfonyl bromide represented by the formula (3) wherein Ar is as defined above in water-containing organic solvent.

  一种制备式(1)代表的氮杂环丁酮衍生物的工艺，其中R1代表取代或未取代的芳基、取代或未取代的苯基甲基或取代或未取代的苯氧基甲基，R2代表氢原子或保护羧酸的基团，Ar代表取代或未取代的苯基，该工艺包括在含水有机溶剂中将式(2)代表的噻唑啉酮衍生物（其中R1和R2如上定义）与式(3)代表的磺酰溴反应，其中Ar如上定义。
• TORII, SIGERU;TANAKA, HIDEO;OGATA, YUZURU;SASAOKA, MICHIO;SAITO, NORIO;NA+
  作者：TORII, SIGERU、TANAKA, HIDEO、OGATA, YUZURU、SASAOKA, MICHIO、SAITO, NORIO、NA+

  DOI：——

  日期：——
• TORII, SIGERU;TANAKA, HIDEO;TADA, NOBUHITO;NAGAO, SIGEMITSU;SASAOKA, MICH+, CHEM. LETT., 1984, N 6, 877-880
  作者：TORII, SIGERU、TANAKA, HIDEO、TADA, NOBUHITO、NAGAO, SIGEMITSU、SASAOKA, MICH+

  DOI：——

  日期：——