N-(3-fluorophenyl)quinoline-2-carboxamide | 585524-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-fluorophenyl)quinoline-2-carboxamide
• CAS: 585524-36-3
• 化学式: C₁₆H₁₁FN₂O
• 分子量: 266.275
• InChiKey: BQFIYJYVTDZTQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  喹哪啶酸 、 3-氟苯胺 在 1-丙基磷酸酐 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以87%的产率得到N-(3-fluorophenyl)quinoline-2-carboxamide
  参考文献：
  名称：

  An optimized and scalable synthesis of propylphosphonic anhydride for general use

  摘要：

  Propylphosphonic anhydride (T3P (R)) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P (R)) in pure form, in an overall yield of 51% in four steps from commercially available diethyl phosphonate. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.02.126

文献信息

• An optimized and scalable synthesis of propylphosphonic anhydride for general use
  作者：Hana Pizova、Pavel Bobal

  DOI：10.1016/j.tetlet.2015.02.126

  日期：2015.4

  Propylphosphonic anhydride (T3P (R)) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P (R)) in pure form, in an overall yield of 51% in four steps from commercially available diethyl phosphonate. (C) 2015 Elsevier Ltd. All rights reserved.