2-<(2',5'-Dihydroxy-4'-methyl)-phenyl>-essigsaeure | 70318-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-<(2',5'-Dihydroxy-4'-methyl)-phenyl>-essigsaeure
• 英文别名: 2-(2',5'-dihydroxy-4'-methylphenyl)-acetic acid；2,5-dihydroxy-4-methylphenylacetic acid；(2,5-Dihydroxy-4-methyl-phenyl)-essigsaeure；2-(2,5-dihydroxy-4-methylphenyl)acetic acid
• CAS: 70318-70-6
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: XMFOYHLIWBRPMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-<(2',5'-Dihydroxy-4'-methyl)-phenyl>-essigsaeure 生成 5-羟基-6-甲基-1-苯并呋喃-2(3H)-酮
  参考文献：
  名称：

  d'羟基-二醌的转位I.l'羟基-2-二亚甲基-4,4'-二醌-3,6,3'，6'等的合成-五羟基-2,3,6,3'，6 ′-二乙氧基-4,4′-二苯醚

  摘要：

  羟基-二羟基-4,4'-二醌-3,6,3'，（XIV）等五羟基-2,3,6,3'，6'-二甲氧基-4， 4'-diphényle（XXVIII）ontétédécrites。

  DOI：

  10.1002/hlca.19560390614
• 作为产物：
  描述：

  (2,5-dihydroxy-4-methyl-phenyl)-acetic acid hydrazide 在 盐酸 作用下， 生成 2-<(2',5'-Dihydroxy-4'-methyl)-phenyl>-essigsaeure
  参考文献：
  名称：

  d'羟基-二醌的转位I.l'羟基-2-二亚甲基-4,4'-二醌-3,6,3'，6'等的合成-五羟基-2,3,6,3'，6 ′-二乙氧基-4,4′-二苯醚

  摘要：

  羟基-二羟基-4,4'-二醌-3,6,3'，（XIV）等五羟基-2,3,6,3'，6'-二甲氧基-4， 4'-diphényle（XXVIII）ontétédécrites。

  DOI：

  10.1002/hlca.19560390614

文献信息

• Composition based on N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives
  申请人：L'OREAL

  公开号：US20010036446A1

  公开（公告）日：2001-11-01

  Compositions comprising, in a physiologically acceptable medium, N-cholesteryloxycarbonyl-4-para-aminophenol and hydroquinone or one of its derivatives may be used for depigmenting and/or lightening the skin, the body hair, and/or the head hair by applying such a composition to the skin, the body hair, and/or the head hair.

  含有N-胆固醇氧羰基-4-对氨基苯酚和氢醌或其衍生物之一的组合物可用于通过将该组合物应用于皮肤、身体毛发和/或头发来使皮肤、身体毛发和/或头发脱色和/或变白。
• Utilization of derivatives of 2,5-dihydroxyphenyl-carboxylic acids,
  申请人：L'Oreal

  公开号：US05449518A1

  公开（公告）日：1995-09-12

  A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, or ##STR2## R.sub.5 is a hydrogen atom, a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21; R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

  具有脱色作用的化妆品或皮肤学组合物包括2,5-二羟基苯甲酸衍生物、它们的同系物和盐，其中衍生物具有以下结构式：##STR1## 其中：R.sub.1代表OR.sub.5，或##STR2## R.sub.5是氢原子，线性或支链的C.sub.1-C.sub.20烷基基，线性或支链的C.sub.2-C.sub.20烯基基，或被一个或多个羟基或烷氧基取代的C.sub.1-C.sub.20烷基基；r'和r"，相同或不同，代表氢原子，C.sub.1-C.sub.20烷基基，C.sub.2-C.sub.6羟基烷基，或C.sub.3-C.sub.6多羟基烷基，或r'和r"与氮原子一起形成杂环；--(CH.sub.2).sub.n--COR.sub.1链中的碳原子数小于或等于21；R.sub.2和R.sub.3，相同或不同，代表氢原子，线性或支链的C.sub.1-C.sub.4烷基基，或C.sub.1-C.sub.4烷氧基；R.sub.4代表氢原子或线性或支链的C.sub.1-C.sub.4烷基基；n是0到20的整数，但当R.sub.2和R.sub.3代表氢原子时，n大于或等于2。
• Compositions based on direct dyestuffs containing a
  申请人：——

  公开号：US04185958A1

  公开（公告）日：1980-01-29

  A composition suitable for dyeing keratin fibres, especially human hair, is provided comprising a direct dyestuff and, as a levelling agent, a 2,5-dihydroxyphenylcarboxylic acid or a salt thereof.

  提供了一种适用于染色角蛋白纤维，特别是人类头发的组合物，包括一种直接染料和作为均染剂的2,5-二羟基苯甲酸或其盐。
• Derivatives of 2,5-dihydroxyphenylcarboxylic acid
  申请人：L'Oreal

  公开号：US05637756A1

  公开（公告）日：1997-06-10

  A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21; R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

  具有脱色作用的化妆品或皮肤科学组合物包括2,5-二羟基苯甲酸衍生物，它们的同系物以及它们的盐，其中衍生物具有以下结构式：##STR1## 其中：R.sub.1代表OR.sub.5，OH或##STR2## R.sub.5是线性或支链C.sub.1-C.sub.20烷基基团，线性或支链C.sub.2-C.sub.20烯基基团或一个C.sub.1-C.sub.20烷基基团，它被一个或多个羟基或烷氧基取代；r'和r"，相同或不同，代表氢原子，C.sub.1-C.sub.20烷基基团，C.sub.2-C.sub.6羟基烷基基团或C.sub.3-C.sub.6多羟基烷基，或r'和r"与氮原子一起形成杂环；--(CH.sub.2).sub.n --COR.sub.1链中的碳原子数小于或等于21；R.sub.2和R.sub.3，相同或不同，代表氢原子，线性或支链C.sub.1-C.sub.4烷基基团或C.sub.1-C.sub.4烷氧基；R.sub.4代表氢原子或线性或支链C.sub.1-C.sub.4烷基基团；n是0到20的整数，但当R.sub.2和R.sub.3表示氢原子时，n大于或等于2。
• Derivatives of 2,5-dihydroxyphenylcarboxylic acids, and their
  申请人：L'Oreal

  公开号：US05667792A1

  公开（公告）日：1997-09-16

  A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21; R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub. -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

  具有脱色作用的化妆品或皮肤科学组合物包括2,5-二羟基苯甲酸衍生物，它们的同系物和它们的盐，其中衍生物具有以下结构式：##STR1## 其中：R.sub.1代表OR.sub.5，OH或##STR2## R.sub.5是线性或支链C.sub.1-C.sub.20烷基基团，线性或支链C.sub.2-C.sub.20烯基基团，或被一个或多个羟基或烷氧基取代的C.sub.1-C.sub.20烷基基团; r'和r"，相同或不同，代表氢原子，C.sub.1-C.sub.20烷基基团，C.sub.2-C.sub.6羟基烷基基团，或C.sub.3-C.sub.6多羟基烷基，或r'和r"与氮原子一起形成杂环；--（CH.sub.2）.sub.n--COR.sub.1链中的碳原子数小于或等于21；R.sub.2和R.sub.3，相同或不同，代表氢原子，线性或支链C.sub.1-C.sub.4烷基基团或C.sub.1-C.sub.4烷氧基；R.sub.4代表氢原子或线性或支链C.sub.-C.sub.4烷基基团；n是0到20的整数，但当R.sub.2和R.sub.3代表氢原子时，n大于或等于2。