N-(2-苯甲酰基-4-氯苯基)-2-苯基乙酰胺 | 76303-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-苯甲酰基-4-氯苯基)-2-苯基乙酰胺
• 英文名称: 5-Chlor-2-phenylacetaminobenzophenon
• 英文别名: N-(2-benzoyl-4-chlorophenyl)-2-phenylacetamide
• CAS: 76303-78-1
• 化学式: C₂₁H₁₆ClNO₂
• 分子量: 349.817
• InChiKey: FHXJIBCBTAHGDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethylene diamine mono-p-toluenesulfonic acid salt 、 N-(2-苯甲酰基-4-氯苯基)-2-苯基乙酰胺 在 sodium hydroxide 、 zinc(II) chloride 作用下， 生成 5-Benzyl-9-chlor-10b-phenyl-1,2,3,10b-tetrahydroimidazo<1,2-c>chinazolin
  参考文献：
  名称：

  Bahr; Dietz, Pharmazie, 1980, vol. 35, # 5-6, p. 256 - 263

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-5-氯二苯甲酮 、 苯乙酰氯 以 甲苯 为溶剂， 反应 2.0h， 以87%的产率得到N-(2-苯甲酰基-4-氯苯基)-2-苯基乙酰胺
  参考文献：
  名称：

  Different Amino Acid Replacements in CAAX-Tetrapeptide Based Peptidomimetic Farnesyltransferase Inhibitors

  摘要：

  In a series of CAAX-tetrapeptide based farnesyltransferase inhibitors it has been shown that the central AA-dipeptide can be replaced by tranexamic acid, 4-aminobenzenesulfonic acid, and 3-amino-N-(2,3-dimethylphenyl)benzenesulfonamide, respectively, yielding inhibitors active in the low micromolar range. Lipophilic derivatives of these compounds showed moderate anti-proliferative activity against different tumor cell lines. A promising class of peptidomimetic farnesyltransferase inhibitors was discovered through the replacement of the terminal AAX motif of the CAAX-tetrapeptide by 2-acylamino-5-aminobenzophenones.

  DOI：

  10.1002/(sici)1521-4184(19994)332:4<124::aid-ardp124>3.0.co;2-g

文献信息

• Different Amino Acid Replacements in CAAX-Tetrapeptide Based Peptidomimetic Farnesyltransferase Inhibitors
  作者：Martin Schlitzer、Isabel Sattler、Hans-Martin Dahse

  DOI：10.1002/(sici)1521-4184(19994)332:4<124::aid-ardp124>3.0.co;2-g

  日期：1999.4

  In a series of CAAX-tetrapeptide based farnesyltransferase inhibitors it has been shown that the central AA-dipeptide can be replaced by tranexamic acid, 4-aminobenzenesulfonic acid, and 3-amino-N-(2,3-dimethylphenyl)benzenesulfonamide, respectively, yielding inhibitors active in the low micromolar range. Lipophilic derivatives of these compounds showed moderate anti-proliferative activity against different tumor cell lines. A promising class of peptidomimetic farnesyltransferase inhibitors was discovered through the replacement of the terminal AAX motif of the CAAX-tetrapeptide by 2-acylamino-5-aminobenzophenones.
• Bahr; Dietz, Pharmazie, 1980, vol. 35, # 5-6, p. 256 - 263
  作者：Bahr、Dietz

  DOI：——

  日期：——