N-(2-苯甲酰基苯基)-1-苄基-2-吡咯烷羧酰胺 | 105112-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-苯甲酰基苯基)-1-苄基-2-吡咯烷羧酰胺
• 英文名称: (S)-2-(N-benzylprolyl)aminobenzophenone
• 英文别名: PhCH2N(CH2)3CHCONHC6H4COPh-o；2-Pyrrolidinecarboxamide, N-(2-benzoylphenyl)-1-(phenylmethyl)-；N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide
• CAS: 105112-33-2
• 化学式: C₂₅H₂₄N₂O₂
• 分子量: 384.478
• InChiKey: IPSABLMEYFYEHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-苯甲酰基苯基)-1-苄基-2-吡咯烷羧酰胺 、 聚甘氨酸 生成 2-[[[2-(1-Benzylpyrrolidine-2-carbonyl)azanidylphenyl]-phenylmethylidene]amino]acetate;nickel(2+)
  参考文献：
  名称：

  BELOKON, YURI N.;BULYCHEV, ALEKSANDR G.;PAVLOV, VIACHESLAV A.;FEDOROVA, E+, J. CHEM. SOC. PERKIN TRANS PT I,(1988) N 8, C. 2075-2083

  摘要：

  DOI：

文献信息

• [EN] NOVEL CYCLIC BORONATE INHIBITORS OF HCV REPLICATION<br/>[FR] NOUVEAUX INHIBITEURS DE BORONATE CYCLIQUES DE RÉPLICATION DU VIRUS DE L'HÉPATITE C
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2009046098A1

  公开（公告）日：2009-04-09

  Compounds of formula (I) or a salt thereof are provided; wherein R1, R2, R3, R4, R6, R8, R20, R30, Y, Z and n are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicaments for treating viral infection, especially HCV infection are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

  提供了化学式（I）的化合物或其盐；其中R1、R2、R3、R4、R6、R8、R20、R30、Y、Z和n的定义如描述中所述。还公开了将这些化合物用作药物以及用于治疗病毒感染，特别是HCV感染的药物制造中的用途。该发明还包括制备这些化合物和其药物配方的过程。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTONOMIC AND OTHER NEUROLOGICAL DISORDERS
  申请人：KANDULA Mahesh

  公开号：US20150210667A1

  公开（公告）日：2015-07-30

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of autonomic and other neurological disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurogenic orthostatic hypotension (NOH), as well as NOH associated with multiple system atrophy (MSA), familial amyloid polyneuropathy (FAP), pure autonomic failure (PAF), and Parkinson's disease (PD), intradialytic hypotension (IDH) or hemodialysis-induced hypotension, hypotension associated with fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS).

  该发明涉及公式I的化合物或其药用可接受的盐，以及其多晶型、溶剂合物、对映体、立体异构体和水合物。包括公式I化合物的有效量的药物组合物，以及用于治疗自主神经和其他神经系统疾病的方法可以制成口服、颊下、直肠、局部、经皮、经粘膜、静脉、肠道给药、糖浆或注射剂形式。这些组合物可用于治疗神经源性直立性低血压（NOH），以及与多系统萎缩（MSA）、家族性淀粉样多神经病（FAP）、纯自主神经功能衰竭（PAF）和帕金森病（PD）、透析期低血压（IDH）或血液透析诱发的低血压、与纤维肌痛综合症（FMS）和慢性疲劳综合症（CFS）相关的低血压。
• [F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION
  申请人：Dinkelborg Ludger

  公开号：US20100217011A1

  公开（公告）日：2010-08-26

  The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

  描述了[F-18]-标记的L-谷氨酸、[F-18]-标记的L-谷氨酸盐和它们的衍生物，以及它们的合成和用途。
• Production method of optically active 2-[(N-benzylprolyl)amino]benzo-phenone compound
  申请人：Hamada Takayuki

  公开号：US20080108830A1

  公开（公告）日：2008-05-08

  The present invention relates to a production method of optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof, which includes reacting optically active N-benzylproline (1) with 2-amino-5-chlorobenzophenone (2) in acetonitrile and in the presence of an amide compound and thionyl chloride. According to the method of the present invention, optically active 2-[(N-benzylprolyl)amino]-5-chlorobenzophenone (3) or a salt thereof can be conveniently produced at a high purity and in a high yield: wherein * shows an asymmetric carbon atom and the configuration of the asymmetric carbon atom is S or R.

  本发明涉及一种光学活性2-[(N-苄基丙氨基)-5-氯苯基]苯酮(3)或其盐的生产方法，包括在乙腈和酰胺化合物以及氯化亚砜的存在下，将光学活性N-苄基脯氨酸(1)与2-氨基-5-氯苯基苯酮(2)反应。根据本发明的方法，可以方便地高纯度、高产率地生产光学活性2-[(N-苄基丙氨基)-5-氯苯基]苯酮(3)或其盐。其中*表示一个不对称碳原子，其立体构型为S或R。
• Production method of diphenylalanine - NI(II) complex
  申请人：Ajinomoto Co., Inc.

  公开号：EP1918275A1

  公开（公告）日：2008-05-07

  The present invention relates to a production method of a compound represented by the formula (3), which includes reacting a compound represented by the formula (2) with a diphenylmethyl halide compound represented by the formula (1) in the presence of alkali metal alkoxide. According to the method of the present invention, compound (3) can be produced at a high purity and in a high yield. wherein each symbol is as defined in the specification, *1 and *2 each show an asymmetric carbon atom, and the configuration of the asymmetric carbon atom of *1 and *2 is (S,S) or (R,R).

  本发明涉及一种化合物的生产方法，该化合物由式（3）表示，包括在碱金属烷氧化物存在下，将式（2）表示的化合物与式（1）表示的二苯基甲基卤化物化合物反应。根据本发明的方法，可以高纯度且高产率地生产化合物（3）。其中每个符号如规范中定义，*1和*2各表示一个不对称碳原子，不对称碳原子*1和*2的构型为（S，S）或（R，R）。