2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionic acid | 199291-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionic acid
• 英文别名: 2-[1-(4-Methylphenyl)sulfonylpyrrol-2-yl]propanoic acid
• CAS: 199291-13-9
• 化学式: C₁₄H₁₅NO₄S
• 分子量: 293.343
• InChiKey: RTFFEBVDQKTEHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionic acid 以 乙醚 为溶剂， 生成 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionic acid methyl ester
  参考文献：
  名称：

  Rhodium-Catalyzed Hydroformylation of 2-Vinyl- and 3-Vinyl-1-tosylpyrroles As a Convenient Synthetic Route to the Corresponding 2-(1-Tosylpyrrolyl)propanals and Derivatives

  摘要：

  2-(1-Tosylpyrrolyl)propanals 2a-b were conveniently prepared (70% yield) via rhodium-catalyzed hydroformylation of the corresponding 2-vinyl- and 3-vinyl-1-tosylpyrroles 1a-b and successfully transformed into some new derivatives (50-90% yield).

  DOI：

  10.1080/00397919708005459
• 作为产物：
  描述：

  1-tosyl-2-vinyl-1H-pyrrole 在 dodecacarbonyltetrarhodium(0) silver(l) oxide 作用下， 以 苯 为溶剂， 25.0~40.0 ℃ 、16.0 kPa 条件下， 反应 24.0h， 生成 2-[1-(Toluene-4-sulfonyl)-1H-pyrrol-2-yl]-propionic acid
  参考文献：
  名称：

  Rhodium-Catalyzed Hydroformylation of 2-Vinyl- and 3-Vinyl-1-tosylpyrroles As a Convenient Synthetic Route to the Corresponding 2-(1-Tosylpyrrolyl)propanals and Derivatives

  摘要：

  2-(1-Tosylpyrrolyl)propanals 2a-b were conveniently prepared (70% yield) via rhodium-catalyzed hydroformylation of the corresponding 2-vinyl- and 3-vinyl-1-tosylpyrroles 1a-b and successfully transformed into some new derivatives (50-90% yield).

  DOI：

  10.1080/00397919708005459

文献信息

• Rhodium-Catalyzed Hydroformylation of 2-Vinyl- and 3-Vinyl-1-tosylpyrroles As a Convenient Synthetic Route to the Corresponding 2-(1-Tosylpyrrolyl)propanals and Derivatives
  作者：Roberta Settambolo、Aldo Caiazzo、Raffaello Lazzaroni

  DOI：10.1080/00397919708005459

  日期：1997.12

  2-(1-Tosylpyrrolyl)propanals 2a-b were conveniently prepared (70% yield) via rhodium-catalyzed hydroformylation of the corresponding 2-vinyl- and 3-vinyl-1-tosylpyrroles 1a-b and successfully transformed into some new derivatives (50-90% yield).