4-nitrobenzyl 4-methoxybenzoate | 142599-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrobenzyl 4-methoxybenzoate
• 英文别名: 4-methoxy-benzoic acid-(4-nitro-benzyl ester)；4-Methoxy-benzoesaeure-(4-nitro-benzylester)；Anissaeure-(4-nitro-benzylester)；Benzoic acid, 4-methoxy-, (4-nitrophenyl)methyl ester；(4-nitrophenyl)methyl 4-methoxybenzoate
• CAS: 142599-44-8
• 化学式: C₁₅H₁₃NO₅
• 分子量: 287.272
• InChiKey: DCTGPNBSVLWJEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  大茴香酸 生成 4-nitrobenzyl 4-methoxybenzoate
  参考文献：
  名称：

  Holmberg, Acta Chemica Scandinavica (1947), 1952, vol. 6, p. 1137,1400

  摘要：

  DOI：

文献信息

• A metal-free approach for the synthesis of amides/esters with pyridinium salts of phenacyl bromides via oxidative C–C bond cleavage
  作者：Kesari Lakshmi Manasa、Yellaiah Tangella、Namballa Hari Krishna、Mallika Alvala

  DOI：10.3762/bjoc.15.182

  日期：——

  O-benzoylation of various amines/benzyl alcohols with pyridinium salts of phenacyl bromides is demonstrated to generate the corresponding amides and esters. This protocol facilitates the oxidative cleavage of a C–C bond followed by formation of a new C–N/C–O bond in the presence of K2CO3. Various pyridinium salts of phenacyl bromides can be readily transformed into a variety of amides and esters which is an

  用苯甲酰溴的吡啶鎓盐对各种胺/苄醇进行N-和O-苯甲酰化的有效，简单和无金属的合成方法被证明可以生成相应的酰胺和酯。该方案有助于在存在K 2 CO 3的情况下促进C–C键的氧化裂解，然后形成新的C–N / C–O键。苯甲酰溴的各种吡啶鎓盐可以很容易地转化为各种酰胺和酯，这是有机合成中常规酰胺化和酯化的另一种方法。高官能团耐受性，广泛的底物范围和操作简便性是当前方案的突出优点。
• Rhodium-catalyzed synthesis of esters from aryl iodides and alcohols: use of alcohols with/without the assistance of aldehydes as carbon monoxide and nucleophile sources
  作者：Ju Hyun Kim、Hawon Park、Young Keun Chung

  DOI：10.1039/c6ra25723b

  日期：——

  A CO-gas-free rhodium-catalyzed alkoxycarbonylation of aryl iodide with alcohols has been developed. Alcohols, with/without the aid of an aldehyde, were used as a carbon monoxide and nucleophile source. The former synthesis afforded better yields of the alkoxycarbonylated products. Moreover, phenols also afforded phenoxycarbonylation products with high yields.

  已经开发出无醇的铑的芳族碘化物与醇的无CO-气体铑催化的烷氧基羰基化。在/不使用醛的情况下，将醇用作一氧化碳和亲核试剂的来源。前一种合成提供了更高收率的烷氧羰基化产物。此外，酚还以高收率提供了苯氧羰基化产物。
• A Visible‐Light Driven Esterification of Aldehydes Catalyzed by VOSO ₄
  作者：Silvia Gaspa、Luca Ledda、David d'Atri、Andrea Porcheddu、Luisa Pisano、Massimo Carraro、Lidia De Luca

  DOI：10.1002/adsc.202201134

  日期：2023.2.21

  An esterification of the C−H bond of aldehydes promoted by oxidovanadium(IV) sulfate, VIVOSO4, is reported. The process is mediated by visible-light, is carried out at room temperature, in absence of additives and using H2O2 as a benign oxidant. VOSO4 is a commercially available, earth-abundant metal (EAMs) salt, that does not require to be prepared. This report opens intriguing perspectives for the

  据报道，硫酸氧钒 (IV) 促进了醛的 C-H 键酯化，V IV OSO 4。该过程以可见光为媒介，在室温下进行，没有添加剂，使用 H 2 O 2作为良性氧化剂。VOSO 4是一种市售的地球储量丰富的金属 (EAM s ) 盐，无需制备。该报告为钒盐在卤化过程以及 C−H 活化中的扩展应用开辟了有趣的视角，并在地球丰富的金属基催化领域做出了贡献。
• Lyons; Reid, Journal of the American Chemical Society, 1917, vol. 39, p. 1738
  作者：Lyons、Reid

  DOI：——

  日期：——