3-amino-8-bromo-1-(pyridine-4-yl)-2,4-dicyano-9H-fluorene | 1321621-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3-amino-8-bromo-1-(pyridine-4-yl)-2,4-dicyano-9H-fluorene
• 英文别名: 3-amino-8-bromo-1-pyridin-4-yl-9H-fluorene-2,4-dicarbonitrile
• CAS: 1321621-32-2
• 化学式: C₂₀H₁₁BrN₄
• 分子量: 387.238
• InChiKey: IYMHHNFIARVTEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  86.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 4-溴-1-茚酮 、 丙二腈 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.12h， 以48.7%的产率得到3-amino-8-bromo-1-(pyridine-4-yl)-2,4-dicyano-9H-fluorene
  参考文献：
  名称：

  Microwave-Assisted One-Pot Synthesis of 3-Amino-1-aryl-8-bromo-2,4-dicyano-9H-fluorenes in Water

  摘要：

  A series of novel 3-amino-1-aryl-8-bromo -2,4-dicyano-9H-fluorenes derivatives were prepared using arylaldehyde, 4-bromo-indanone, malononitrile, and sodium hydroxide as the reactants in water via one-pot synthesis under microwave irradiation. A green and efficient method was successfully developed via microwave irradiation. The method possesses several advantages, such as environmental friendliness, shorter reaction time, and simple workup procedure.

  DOI：

  10.1080/00397911.2010.517377

文献信息

• Microwave-Assisted One-Pot Synthesis of 3-Amino-1-aryl-8-bromo-2,4-dicyano-9<i>H</i>-fluorenes in Water
  作者：Yixin Zhou、Jianqiang Wang、Renjun Du、Guohua Zhang、Wei Wang、Cheng Guo

  DOI：10.1080/00397911.2010.517377

  日期：2011.11.1

  A series of novel 3-amino-1-aryl-8-bromo -2,4-dicyano-9H-fluorenes derivatives were prepared using arylaldehyde, 4-bromo-indanone, malononitrile, and sodium hydroxide as the reactants in water via one-pot synthesis under microwave irradiation. A green and efficient method was successfully developed via microwave irradiation. The method possesses several advantages, such as environmental friendliness, shorter reaction time, and simple workup procedure.