N-(3-氟苯基)-N-(甲基磺酰基)甘氨酸 | 667877-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-氟苯基)-N-(甲基磺酰基)甘氨酸
• 英文名称: N-(3-fluorophenyl)-N-(methylsulfonyl)glycine
• 英文别名: 2-(3-fluoro-N-methylsulfonylanilino)acetic acid
• CAS: 667877-45-4
• 化学式: C₉H₁₀FNO₄S
• mdl: MFCD03865656
• 分子量: 247.25
• InChiKey: AKSFHQCWQBEFTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS AND METHODS FOR SYNERGISTIC ACTIVATION OF M CHANNELS<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR L'ACTIVATION SYNERGIQUE DES CANAUX M
  申请人：UNIV CALIFORNIA

  公开号：WO2020018839A1

  公开（公告）日：2020-01-23

  A method of activating heteromeric KCNQ2/3, KCNQ3/5, or KCNQ4/5 voltage-gated potassium channels in a cell membrane is described, as are compositions for use with same, as well as methods of reducing neuronal excitability and of ameliorating symptoms of epilepsy, anxiety, neuropathic pain, hypertension, cardiovascular disease, a neurodegenerative disorder, alcohol withdrawal, cancer, inflammation, or ophthalmic disease in a subject. These KCNQ2/3 (or KCNQ3/5 or KCNQ4/5) channels are heteromers that comprise KCNQ2 (or KCNQ5) subunits and KCNQ3 (or KCNQ4) subunits. In one embodiment, the method comprises: (a) contacting the cell membrane with a first agent that binds a KCNQ2 (or KCNQ5) subunit; and (b) contacting the cell membrane with a second agent that binds a KCNQ3 (or KCNQ4) subunit.