5-cholesten-3β-yl (p-hydroxybenzenesulfonate) | 381704-90-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5-cholesten-3β-yl (p-hydroxybenzenesulfonate)
• 英文别名: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 4-hydroxybenzenesulfonate
• CAS: 381704-90-1
• 化学式: C₃₃H₅₀O₄S
• 分子量: 542.824
• InChiKey: IVTOWAFGSQIZEV-HMSQZKPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对新戊酰氧基苯磺酰氯 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 5-cholesten-3β-yl (p-hydroxybenzenesulfonate)
  参考文献：
  名称：

  SYNTHESIS OF SOLID-PHASE BOUND SULFONATE ESTERS

  摘要：

  p-Pivaloyloxybenzenesulfonyl and methylsulfonyl residues were used as linkers to attach secondary alcohols to Wang resin and to Merrifield resin, respectively. p-Pivaloyloxybenzenesulfonates of alcohols were deprotected at the phenolic group and coupled with Wang resin by Mitsunobu reaction whereas mesylates were lithiated at the methyl group and subsequently connected with chloromethyl residues of Merrifield resin.

  DOI：

  10.1081/scc-100105328

文献信息

• SYNTHESIS OF SOLID-PHASE BOUND SULFONATE ESTERS
  作者：Bartlomiej Furman、Robert Łysek、Łukasz Matyjasek、Wojciech Wojtkielewicz、Marek Chmielewski

  DOI：10.1081/scc-100105328

  日期：2001.1

  p-Pivaloyloxybenzenesulfonyl and methylsulfonyl residues were used as linkers to attach secondary alcohols to Wang resin and to Merrifield resin, respectively. p-Pivaloyloxybenzenesulfonates of alcohols were deprotected at the phenolic group and coupled with Wang resin by Mitsunobu reaction whereas mesylates were lithiated at the methyl group and subsequently connected with chloromethyl residues of Merrifield resin.