3-Nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-Nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide
• 英文别名: 3-nitro-N-(1-propylbenzimidazol-2-yl)benzamide
• 化学式: C17H16N4O3
• 分子量: 324.33
• InChiKey: JLLIANWHDQWCMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
  申请人：Duke University

  公开号：US10927083B2

  公开（公告）日：2021-02-23

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.

  本发明提供了具有式（II）的 TAK1 抑制剂、亲和树脂和荧光染料，以及使用此类化合物治疗各种疾病或分离或纯化蛋白质的方法。
• SUBSTITUTED BENZIMIDAZOLE AND BENZOTHIAZOLE INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE AND METHODS OF USE THEREOF
  申请人：Duke University

  公开号：US20190263759A1

  公开（公告）日：2019-08-29

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.
• SUBSTITUTED BENZIMIDAZOLES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE
  申请人：Duke University

  公开号：US20210188783A1

  公开（公告）日：2021-06-24

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.