3-(4-Methoxyphenyl)-2,2,2-triphenyl-1,4,2lambda5-benzothiazaphosphinine | 1263066-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Methoxyphenyl)-2,2,2-triphenyl-1,4,2lambda5-benzothiazaphosphinine
• 英文别名: 3-(4-methoxyphenyl)-2,2,2-triphenyl-1,4,2λ5-benzothiazaphosphinine
• CAS: 1263066-78-9
• 化学式: C₃₂H₂₆NOPS
• 分子量: 503.604
• InChiKey: KIQZQDGUMIZZOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  46.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三苯基膦 、 N-((OMe)phenyl)thiosalicylaldimine 在 盐酸 、 palladium dichloride 作用下， 以 甲醇 、 水 、 四氢呋喃 为溶剂， 反应 6.0h， 生成 3-(4-Methoxyphenyl)-2,2,2-triphenyl-1,4,2lambda5-benzothiazaphosphinine
  参考文献：
  名称：

  Friendly Synthesis, Metallation, and Phosphorylation of Schiff Base as a Potential Pharmacological Interest

  摘要：

  In view of the broad physiological activity of organometallic and organophosphorus compounds, the present paper deals with the synthesis of 2-(4-methoxybenzylidene amino) benzene-thiol, its metallation with mercury (II), nickel (II), palladium (II), and phosphorylation. The antimicrobial activities of all products were investigated. The palladated product displays a significant anticancer activity against human breast carcinoma cell. All the new products were investigated and their structures were elucidated using elemental analyses, thermal analysis, and spectroscopic data.

  DOI：

  10.1080/15533174.2010.522662

文献信息

• Friendly Synthesis, Metallation, and Phosphorylation of Schiff Base as a Potential Pharmacological Interest
  作者：Emtithal A. El-Sawi、Mona A. Hosny、Wafaa A. Mokbel、Tahany M. Sayed

  DOI：10.1080/15533174.2010.522662

  日期：2010.11.30

  In view of the broad physiological activity of organometallic and organophosphorus compounds, the present paper deals with the synthesis of 2-(4-methoxybenzylidene amino) benzene-thiol, its metallation with mercury (II), nickel (II), palladium (II), and phosphorylation. The antimicrobial activities of all products were investigated. The palladated product displays a significant anticancer activity against human breast carcinoma cell. All the new products were investigated and their structures were elucidated using elemental analyses, thermal analysis, and spectroscopic data.