Thiamin-allyl-disulfid | 554-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Thiamin-allyl-disulfid
• 英文别名: N-(2-allyldisulfanyl-4-hydroxy-1-methyl-but-1-enyl)-N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formamide；Allithiamine；N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(prop-2-enyldisulfanyl)pent-2-en-2-yl]formamide
• CAS: 554-44-9
• 化学式: C₁₅H₂₂N₄O₂S₂
• 分子量: 354.497
• InChiKey: WNCAVNGLACHSRZ-SDNWHVSQSA-N

物化性质

• 熔点：
  141-142℃ (Decomposition) (water )
• 沸点：
  584.3±50.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3 (20 ºC 760 Torr)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• COMPOUND CAPABLE OF INTRACEREBRAL RESIDENCE AND USE THEREOF
  申请人：DRUG DELIVERY SYSTEM INSTITUTE, LTD.

  公开号：EP0614886A1

  公开（公告）日：1994-09-14

  A group of novel compounds which can pass through the blood-brain barrier (BBB) with a drug carried thereon and reside in the brain to release the drug and a group of known compounds having the above characteristics. More specifically, a compound represented by general formula (Ia) and a salt thereof, wherein R¹ represents hydroxy, carboxy, amino which may be substituted by C₁-C₆ alkyl, or C₁-C₆ alkyl which may be substituted by a 5-to 7-membered saturated heterocyclic group, R² represents hydrogen or C₁-C₆ alkyl, R³ represents hydrogen or C₁-C₆ alkyl which may be hydroxylated, R⁴ represents hydrogen or C₁-C₆ alkyl, R⁵ represents amino acid residue, or -S-R⁶ or -CO-R⁶ (wherein R⁶ represents C₁-C₁₄ alkyl which may be substituted by a 5- to 7-membered saturated heterocyclic group, C₁-C₁₄ alkyl, C₂-C₆ alkenyl, aryl or a 5- to 7-membered saturated ring group), or a group represented by general formula (IVa), wherein R¹, R², R³ and R⁴ are each as defined above, and symbol ......... represents either a single or a double bond, provided that at least one of R¹, R³ and R⁵ represents hydroxy, carboxy or amino.

  一组可携带药物通过血脑屏障（BBB）并驻留在大脑中释放药物的新型化合物和一组具有上述特征的已知化合物。更具体地说，通式 (Ia) 所代表的化合物及其盐，其中 R¹ 代表羟基、羧基、可被 C₁-C₆ 烷基取代的氨基、或可被 5-7 元饱和杂环基团取代的 C₁-C₆ 烷基，R² 代表氢或 C₁-C₆ 烷基，R³ 代表氢或可被羟基化的 C₁-C₆ 烷基，R⁴ 代表氢或 C₁-C₆ 烷基、R⁵ 代表氨基酸残基，或 -S-R⁶ 或 -CO-R⁶（其中 R⁶ 代表 C₁-C₁₄ 烷基，该烷基可被 5-7 元饱和杂环基、C₁-C₁₄ 烷基取代、C₂-C₆烯基、芳基或 5-7 元饱和环基）或通式 (IVa) 所代表的基团，其中 R¹、R²、R³ 和 R⁴ 各如上所定义，符号 ......... 代表单键或双键，条件是 R¹、R³ 和 R⁵ 中至少有一个代表羟基、羧基或氨基。
• Compositions and Methods for Treatment of Prediabetes
  申请人：Cross, III William H.

  公开号：US20170312329A1

  公开（公告）日：2017-11-02

  The invention provides compositions and methods to treat prediabetes. In particular, the inventor has discovered that particular combinations of diverse types of antioxidants have synergistic and surprising effects for use against prediabetes. The composition includes: a plurality of heteroatom-based antioxidants having the formula X—CH 2 —CH(R)—(CH 2 ) m —Z; a plurality of antioxidants with a conjugated segment; an antioxidant that is a flavan-3-ol; and an antioxidant that contains a disulfide bond. The antioxidants are chosen such that at least one has a pro-oxidative effect.
• US5580904A
  申请人：——

  公开号：US5580904A

  公开（公告）日：1996-12-03