N-(3-甲氧基苯基)-N-苯基-乙酰胺 | 101651-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-甲氧基苯基)-N-苯基-乙酰胺
• 英文名称: N-(3-methoxyphenyl)acetanilide
• 英文别名: N-(m-Methoxyphenyl)-N-phenylacetamide；N-(3-methoxyphenyl)-N-phenylacetamide
• CAS: 101651-37-0
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.29
• InChiKey: WKAIOPWAPFOJFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-甲氧基苯基)-N-苯基-乙酰胺 在 氢氧化钾 作用下， 以 乙醇 、 正己烷 为溶剂， 反应 9.5h， 生成 4-methoxy-9H-carbazole
  参考文献：
  名称：

  Hewlins, Michael J. E.; Jackson, Anthony H.; Long, Anthony, Journal of Chemical Research, Miniprint, 1986, # 8, p. 2645 - 2696

  摘要：

  DOI：
• 作为产物：
  描述：

  N-乙酰苯胺 、 三氟甲烷磺酸3-甲氧基-2-(三甲基硅基)苯酯 在 四丁基二氟三苯硅酸铵 作用下， 以 甲苯 为溶剂， 反应 28.0h， 以70%的产率得到N-(3-甲氧基苯基)-N-苯基-乙酰胺
  参考文献：
  名称：

  A facile N-arylation of acetanilides with arynes

  摘要：

  An efficient, mild and transition-metal-free method for the N-arylation of acetanilides, leading to a range of unsymmetrical diarylamine products is reported. Reactions of ortho-silylaryl triflates with acetanilides in the presence of tetrabutylammonium triphenyldifluorosilicate (TBAT) in toluene afforded the desired products in good to excellent yields. Regioselectivity was also observed when unsymmetrical aryne precursors were used. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.146

文献信息

• 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same
  申请人：Japan Tobacco, Inc.

  公开号：US06235730B1

  公开（公告）日：2001-05-22

  3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 3, R3 and R4 independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.

  本发明提供了3-哌啶基-4-氧喹唑啉衍生物，其由式（I）表示：其中R代表氨基或环氨基，例如二苯并氮杂环，每个都被取代或未取代的芳基基团，取代或未取代的杂环基团或类似物所取代，n是1到3的整数，R3和R4独立地表示氢原子，低碳基或类似物，或其药学上可接受的盐。本发明化合物（I）具有出色的MTP抑制活性。因此，这些化合物不仅抑制了导致动脉硬化疾病的LDL的形成，还通过调节MTP活性来调节血液中的TG，胆固醇和脂蛋白如LDL，并通过调节细胞脂质来使用作为新型的高脂血症或动脉硬化疾病的预防或治疗药物。此外，它们还可以用作胰腺炎，肥胖症，高胆固醇血症和高三酰甘油血症的治疗或预防剂。
• Exploiting the Marcus inverted region for first-row transition metal–based photoredox catalysis
  作者：Amy Y. Chan、Atanu Ghosh、Jonathan T. Yarranton、Jack Twilton、Jian Jin、Daniela M. Arias-Rotondo、Holt A. Sakai、James K. McCusker、David W. C. MacMillan

  DOI：10.1126/science.adj0612

  日期：2023.10.13

  Second- and third-row transition metal complexes are widely employed in photocatalysis, whereas earth-abundant first-row transition metals have found only limited use because of the prohibitively fast decay of their excited states. We report an unforeseen reactivity mode for productive photocatalysis that uses cobalt polypyridyl complexes as photocatalysts by exploiting Marcus inverted region behavior

  第二和第三行过渡金属络合物广泛应用于光催化，而地球上丰富的第一行过渡金属由于其激发态的快速衰减而仅具有有限的用途。我们报告了一种不可预见的高效光催化反应模式，该模式利用钴聚吡啶配合物作为光催化剂，利用马库斯倒置区域行为，将激发态能量的增加与激发态寿命的增加结合起来。这些钴 (III) 配合物凭借其强大的氧化还原电位和足够长的激发态寿命可以参与双分子反应，催化氧化 C(sp 2 )–芳基酰胺与具有挑战性的位阻芳基硼酸的 N 偶联。更一般地说，结果意味着发色团可以设计为增加激发态寿命，同时增加激发态能量，为使用相对丰富的金属作为光氧化还原催化剂提供了途径。
• 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME
  申请人：Japan Tobacco Inc.

  公开号：EP0970954A1

  公开（公告）日：2000-01-12

  3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 4, R3 and R4 independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.

  提供了3-哌啶基-4-氧代喹唑啉衍生物，由式(I)表示： 其中 R 代表氨基或环状氨基，如二苯并氮杂卓，它们各自被取代或未被取代的芳基、取代或未被取代的杂芳基或类似基团取代，n 是 1 至 4 的整数，R3 和 R4 独立地代表氢原子、低级烷基或类似基团，或其药学上可接受的盐。本发明的化合物（I）具有优异的 MTP 抑制活性。因此，这些化合物不仅能抑制导致动脉硬化疾病的低密度脂蛋白的形成，还能调节血液中的总胆固醇、胆固醇和脂蛋白（如低密度脂蛋白），并通过调节 MTP 活性来调节细胞脂质。它们还可用作高脂血症或动脉硬化疾病的新型预防或治疗药物。此外，它们还可用作胰腺炎、肥胖症、高胆固醇血症和高甘油三酯血症的治疗或预防药物。
• HEWLINS M. J. E.; JACKSON A. H.; LONG A.; OLIVEIRA-CAMPOS A.; SHANNON P. +, J. CHEM. RES. SYNOP.,(1986) N 8, 292-293
  作者：HEWLINS M. J. E.、 JACKSON A. H.、 LONG A.、 OLIVEIRA-CAMPOS A.、 SHANNON P. +

  DOI：——

  日期：——
• US6235730B1
  申请人：——

  公开号：US6235730B1

  公开（公告）日：2001-05-22