(1S)-1-phenylethyl (2-furylmethyl)carbamate | 1007604-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S)-1-phenylethyl (2-furylmethyl)carbamate
• 英文别名: [(1S)-1-phenylethyl] N-(furan-2-ylmethyl)carbamate
• CAS: 1007604-35-4
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.278
• InChiKey: DMUMPHHHLBDFKV-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S)-1-phenylethyl (2-furylmethyl)carbamate 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 4.25h， 生成
  参考文献：
  名称：

  Practical, Scalable, High-Throughput Approaches to η³-Pyranyl and η³-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction

  摘要：

  [GRAPHICS]A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and. TpMO(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.

  DOI：

  10.1021/jo702006z
• 作为产物：
  描述：

  (S)-1-phenylethyl 1H-imidazole-1-carboxylate 、 2-呋喃甲胺 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以96%的产率得到(1S)-1-phenylethyl (2-furylmethyl)carbamate
  参考文献：
  名称：

  Practical, Scalable, High-Throughput Approaches to η³-Pyranyl and η³-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction

  摘要：

  [GRAPHICS]A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and. TpMO(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.

  DOI：

  10.1021/jo702006z

文献信息

• Practical, Scalable, High-Throughput Approaches to η³-Pyranyl and η³-Pyridinyl Organometallic Enantiomeric Scaffolds Using the Achmatowicz Reaction
  作者：Thomas C. Coombs、Lee、Heilam Wong、Matthew Armstrong、Bo Cheng、Wenyong Chen、Alessandro F. Moretto、Lanny S. Liebeskind

  DOI：10.1021/jo702006z

  日期：2008.2.1

  [GRAPHICS]A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and. TpMO(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions.