[Ru(bpy)2]Cl2·3H2O | 77011-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Ru(bpy)2]Cl2·3H2O
• 英文别名: Ru(bpy)2Cl2；Ru(2,2'-bipyridine)Cl2；Ru(bpy)Cl2；(2,2'-Bipyridine)dichlororuthenate (II)；dichlororuthenium;2-pyridin-2-ylpyridine
• CAS: 77011-27-9
• 化学式: C₁₀H₈Cl₂N₂Ru
• 分子量: 328.163
• InChiKey: NAMUWYTVNFXKSG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [Ru(bpy)2]Cl2·3H2O 、 [(10',15',20'-triphenyl)porphyrin(5'-p-phenoxy-5-ethanamido)]-1,10-phenantholine 在 溶剂黄146 作用下， 反应 2.0h， 以35.1%的产率得到[bis(bipyridine){[(10',15',20'-triphenyl)porphyrin(5'-p-phenoxy-5-ethanamido)]-1,10-phenantholine}ruthenium (II)]
  参考文献：
  名称：

  An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

  摘要：

  An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 +/- 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. (C) 2009 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2009.10.004

文献信息

• Synthesis and spectroscopic properties of di-2-pyridyl sulfide (dps) compounds. Crystal structure of [Ru(dps)₂Cl₂]
  作者：Giuseppe Bruno、Franco Nicolò、Sanda Lo Schiavo、Maria S. Sinicropi、Giuseppe Tresoldi

  DOI：10.1039/dt9950000017

  日期：——

  sulfide)ruthenium(II) complexes containing the ligands CI, NO2, NO, MeCN, py (pyridine), pyz (pyrazine) or 4,4′-bipy (4,4′-bipyridine) have been prepared by usual methods and a new direct procedure from robust [Ru(dps)2CI2]1a(dps = di-2-pyridyl sulfide). This is the main product of the reaction between dps and RuCl3 in refluxing dimethylformamide (dmf) while minor products are the complexes [Ru(dps)(dmf)(CO)CI2]

  含有配体CI，NO 2，NO，MeCN，py（吡啶），pyz（吡嗪）或4,4'-bipy（4,4'-bipyridine）的双（二-2-吡啶硫基）钌（II）配合物已经通过常规方法和新的直接方法从稳健的[Ru（dps）2 CI 2 ] 1a（dps =二-2-吡啶基硫醚）制备了该化合物。这是dps和RuCl 3在回流的二甲基甲酰胺（dmf）中反应的主要产物，次要产物是[Ru（dps）（dmf）（CO）CI 2 ]和[Ru（dps）2（CO）Cl ] [PF 6 ]。已确定1a的晶体结构：斜方晶，空间群Pbcn，a= 8.587（2），b = 16.421（3），c = 15.023（3）Å，Z = 4，R = 0.024。Ru原子表现出几乎理想的八面体配位几何结构，其中包括两个位于顺式位置的CI原子，两个dps配体通过各自的吡啶N原子螯合。每个dps都采用扭曲的N，N-内部构象。六元螯合物环
• DNA binding ad photocleavage properties of cationic porphyrin-polypyridyl ruthenium(II) hybrids
  作者：Ping Zhao、Jun Li、Li-Jun Yang、Jia-Zheng Lu、Hai-Min Guo、Li-Na Ma、Bing-Hui Ou

  DOI：10.1080/00958972.2013.866234

  日期：2013.12.10

  Three cationic porphyrin-polypyridyl ruthenium(II) hybrids, differing in the planar areas of the polypyridyl moieties, were synthesized and their interactions with DNA investigated using absorption and fluorescence titration, induced circular dichroism spectra, thermal DNA denaturation measurements, as well as surface-enhanced Raman spectroscopy. Ethidium bromide competition experiments determined the binding affinity constants (K-b) of these compounds for CT DNA. DNA photocleavage experiments indicated that these hybrids have a broader cleaving wavelength range than traditional drugs and O-1(2) is the reactive species responsible for the cleavage. The proper planar area was proved to be responsible for the larger K-b and higher DNA photocleavage efficiency.
• An amphiphilic ruthenium(II)–polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent
  作者：Chun-Ting Poon、Pui-Shan Chan、Cornelia Man、Feng-Lei Jiang、Ricky Ngok Shun Wong、Nai-Ki Mak、Daniel W.J. Kwong、Sai-Wah Tsao、Wai-Kwok Wong

  DOI：10.1016/j.jinorgbio.2009.10.004

  日期：2010.1

  An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 +/- 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. (C) 2009 Elsevier Inc. All rights reserved.