N-(3-碘苯基甲基)丙基胺 | 90389-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-碘苯基甲基)丙基胺
• 英文名称: (3-Iodo-benzyl)-propyl-amine
• 英文别名: Benzenemethanamine, 3-iodo-N-propyl-；N-[(3-iodophenyl)methyl]propan-1-amine
• CAS: 90389-95-0
• 化学式: C₁₀H₁₄IN
• 分子量: 275.132
• InChiKey: LEPFIZCLEIWUJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-碘苯甲醛 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 N-(3-碘苯基甲基)丙基胺
  参考文献：
  名称：

  Benzylamines: synthesis and evaluation of antimycobacterial properties

  摘要：

  The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 micrograms/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combinations of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.

  DOI：

  10.1021/jm00375a005

文献信息

• METHOD AND DEVICE FOR DETECTION OF NITROAMINES
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.

  公开号：EP2510350A2

  公开（公告）日：2012-10-17
• [EN] METHOD AND DEVICE FOR DETECTION OF NITROAMINES<br/>[FR] PROCÉDÉ ET DISPOSITIF DE DÉTECTION DE NITROAMINES
  申请人：YISSUM RES DEV CO

  公开号：WO2011070572A2

  公开（公告）日：2011-06-16

  An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.
• [EN] METHOD AND DEVICE FOR DETECTION OF NITRAMINES<br/>[FR] PROCÉDÉ ET DISPOSITIF DE DÉTECTION DE NITROAMINES
  申请人：YISSUM RES DEV CO

  公开号：WO2011070572A3

  公开（公告）日：2011-10-06

  [EN] Voltammetric or SPR based sensors for determining non - aromatic, non-planar nitramine analytes, especially RDX explosive, using pi donor-acceptor interactions, comprise a matrix network of gold nanoparticles (AuNPs) and electropolymerised p - aminothiophenol (PATP)with pi-donor cavities, preferably formed by template imprinting using Kemp's acid, cis - 1, 3, 5 - trimethylcyclohexane - 1, 3, 5 - tricarboxylic acid (CAS RN = 90389 -95 -0)
  [FR] La présente invention concerne un procédé ultrasensible de détection d'analytes nitroamine non planaires non aromatiques dans un échantillon.