N-(1-((1R)-1-(4-(2,5-dimethylpyrrolidine-1-carbonyl)phenyl)ethylcarbamoyl)cyclopropyl)-3-fluoro-5-(trifluoromethyl)benzamide | 1134772-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-((1R)-1-(4-(2,5-dimethylpyrrolidine-1-carbonyl)phenyl)ethylcarbamoyl)cyclopropyl)-3-fluoro-5-(trifluoromethyl)benzamide
• 英文别名: N-[1-[[(1R)-1-[4-(2,5-dimethylpyrrolidine-1-carbonyl)phenyl]ethyl]carbamoyl]cyclopropyl]-3-fluoro-5-(trifluoromethyl)benzamide
• CAS: 1134772-87-4
• 化学式: C₂₇H₂₉F₄N₃O₃
• 分子量: 519.539
• InChiKey: GQCQGYALDUZEBP-OFLPRAFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.5
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,5-二甲基吡咯烷 、 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(1-((1R)-1-(4-(2,5-dimethylpyrrolidine-1-carbonyl)phenyl)ethylcarbamoyl)cyclopropyl)-3-fluoro-5-(trifluoromethyl)benzamide
  参考文献：
  名称：

  Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazides

  摘要：

  The synthesis and SAR of two series of bradykinin B-1 receptor antagonists is described. The benzamide moiety proved to be a suitable replacement for the aryl ester functionality of biaryl based antagonists. In addition, it was found that semicarbazides can effectively replace cyclopropyl amino acids. The compounds with the best overall pro. le were biaryl semicarbazides which display high antagonistic activity, low Caco-2 efflux and high oral bioavailability in the rat. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.119

文献信息

• Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazides
  作者：Marco Schaudt、Elsa Locardi、Gunther Zischinsky、Roland Stragies、Jochen R. Pfeifer、Christoph Gibson、Dirk Scharn、Uwe Richter、Holger Kalkhof、Klaus Dinkel、Karsten Schnatbaum

  DOI：10.1016/j.bmcl.2009.11.119

  日期：2010.2

  The synthesis and SAR of two series of bradykinin B-1 receptor antagonists is described. The benzamide moiety proved to be a suitable replacement for the aryl ester functionality of biaryl based antagonists. In addition, it was found that semicarbazides can effectively replace cyclopropyl amino acids. The compounds with the best overall pro. le were biaryl semicarbazides which display high antagonistic activity, low Caco-2 efflux and high oral bioavailability in the rat. (C) 2009 Elsevier Ltd. All rights reserved.