2-dodecylbromobenzene | 105802-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-dodecylbromobenzene
• 英文别名: 1-(2-bromo-phenyl)-dodecane；1-(2-Brom-phenyl)-dodecan；1-bromo-2-dodecylbenzene
• CAS: 105802-27-5
• 化学式: C₁₈H₂₉Br
• 分子量: 325.332
• InChiKey: SCHYCRCDRYWPGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-dodecylbromobenzene 、 丙烯醛 生成 1-(2-Dodecylphenyl)-1-hydroxy-2-propene
  参考文献：
  名称：

  GLEASON, JOHN G.;HALL, RALPH F.;KU, THOMAS WEN-FU;PERCHONOCK, CARL D.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴苯甲酰氯 在 sodium hydroxide 、 Diundecylcadmium 、 一水合肼 、 二乙二醇 、 苯 作用下， 生成 2-dodecylbromobenzene
  参考文献：
  名称：

  Sulfination of Aryllithium Compounds. The Preparation of Sodium o-, m-, and p-n-Dodecylbenzenesulfonates¹

  摘要：

  DOI：

  10.1021/ja01145a046

文献信息

• Method for producing biaryl compound
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20030158419A1

  公开（公告）日：2003-08-21

  There is disclosed a method for producing a biaryl compound of formula (I): 1 wherein R 1 is the same or different and independently denotes a substituted or unsubstituted hydrocarbon group or the like, A and B denote an aromatic hydrocarbon ring having from 6 to 14 carbon atoms or the like, k and m independently denote an integer of from 0 to 5, and 1 denotes an integer of 1 or 2, which method is characterized by reacting an aromatic compound of formula (II): 2 wherein R 1 , k and l denote the same as defined above, and X 1 denotes a leaving group, with a Grignard reagent of formula (III): 3 (R 2 ). 9MgX 2 (IIIg) wherein R 2 , B, and m denote the same as defined above and X 2 denotes chlorine or the like, in the presence of a cyclic ether, or an acyclic ether having two or more ether oxygens in the molecule and a nickel catalyst.

  揭示了一种制备式(I)的联苯化合物的方法：其中R1相同或不同且独立地表示取代或未取代的碳氢化合物基团或类似物，A和B表示具有6至14个碳原子或类似物的芳香碳氢环，k和m独立地表示0至5的整数，l表示1或2的整数，该方法的特征在于将式(II)的芳香化合物：其中R1、k和l的定义与上述相同，X1表示离去基团，与式(III)的格氏试剂反应：其中R2、B和m的定义与上述相同，X2表示氯或类似物，在环醚或分子中具有两个或更多个醚氧原子的无环醚和镍催化剂的存在下。
• Leukotriene antagonists
  申请人：SmithKline Beecham Corporation

  公开号：US04939279A1

  公开（公告）日：1990-07-03

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代基取代基的脂肪酸化合物，其可用作白三烯拮抗剂和含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯是因素的疾病的方法。
• Thiophenyl Alkanoic acids useful as leukotriene antagonists
  申请人：Smithkline Beckman Corporation

  公开号：US04874792A1

  公开（公告）日：1989-10-17

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代基取代基的脂肪酸化合物，其可用作白三烯拮抗剂和含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯是因素的疾病。
• Intermediates for the preparation of leukotriene antagonists
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0358240A2

  公开（公告）日：1990-03-14

  Intermediates of structure: wherein Y is CO₂R₁₀ or CH(R₁₂)CO₂R₁₀ in which R₁₀ is an ester protective group and R₁₀ is hydrogen, methyl, methoxy or fluoro, and their use for the preparation of leukotriene antagonists.

  结构的中间体： 其中 Y 是 CO₂R₁₀ 或 CH(R₁₂)CO₂R₁₀，其中 R₁₀ 是酯保护基团，R₁₀ 是氢、甲基、甲氧基或氟，以及它们在制备白三烯拮抗剂中的用途。
• INK COMPOSITIONS AND QUANTUM DOT POLYMER COMPOSITE PATTERN PREPARED FROM THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3805337A1

  公开（公告）日：2021-04-14

  An ink composition, including a quantum dot; a metal catalyst; an aromatic halide compound; an ene compound including at least one C-H moiety and a carbon-carbon unsaturated bond; and optionally, a metal oxide particle, wherein the metal catalyst is a metal salt, a metal coordination complex, or a combination thereof, wherein the metal catalyst comprises a metal that is palladium, nickel, ruthenium, rhodium, iridium, iron, cobalt, chromium, copper, platinum, silver, gold, or a combination thereof.

  一种墨水组合物，包括量子点；金属催化剂；芳香族卤化物化合物；烯化合物，包括至少一个C-H分子和一个碳-碳不饱和键；以及可选的金属氧化物颗粒，其中金属催化剂是金属盐、金属配位络合物或它们的组合，其中金属催化剂包括钯、镍、钌、铑、铱、铁、钴、铬、铜、铂、银、金或它们的组合。