2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide | 877077-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide
• 英文别名: N-diazo-2,3-dioxo-1,4-dihydroquinoxaline-6-sulfonamide
• CAS: 877077-99-1
• 化学式: C₈H₅N₅O₄S
• 分子量: 267.225
• InChiKey: XDIGWNMOLGCBLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 反应 1.5h， 以90%的产率得到2,3-dichloroquinoxaline-6-sulfonyl azide
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Some 2(1H)-quinoxalinone-6-sulfonyl Derivatives

  摘要：

  The synthesis of some quinoxalinesulfonyl derivatives is described. Two of the synthesized derivatives, 2-oxo-1,2-dihydroquinoxaline-6-sulfonyl azide (3a) and 2,3dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (3b), were screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and seven strains of Gram-negative bacteria, along with two fungal isolates. The two compounds showed broad spectrum (in vitro) activity against the bacterial strains.

  DOI：

  10.1080/104265090889396
• 作为产物：
  描述：

  2,3-二氧代-1,2,3,4-四氢喹噁啉-6-磺酰氯 在 sodium azide 作用下， 以 丙酮 为溶剂， 反应 8.0h， 以91%的产率得到2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Some 2(1H)-quinoxalinone-6-sulfonyl Derivatives

  摘要：

  The synthesis of some quinoxalinesulfonyl derivatives is described. Two of the synthesized derivatives, 2-oxo-1,2-dihydroquinoxaline-6-sulfonyl azide (3a) and 2,3dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (3b), were screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and seven strains of Gram-negative bacteria, along with two fungal isolates. The two compounds showed broad spectrum (in vitro) activity against the bacterial strains.

  DOI：

  10.1080/104265090889396

文献信息

• Synthesis and Antimicrobial Activity of Some 2(1H)-quinoxalinone-6-sulfonyl Derivatives
  作者：Craig A. Obafemi、D. A. Akinpelu

  DOI：10.1080/104265090889396

  日期：2005.8.1

  The synthesis of some quinoxalinesulfonyl derivatives is described. Two of the synthesized derivatives, 2-oxo-1,2-dihydroquinoxaline-6-sulfonyl azide (3a) and 2,3dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (3b), were screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and seven strains of Gram-negative bacteria, along with two fungal isolates. The two compounds showed broad spectrum (in vitro) activity against the bacterial strains.