4-methyl-1-(3-sulfopropyl)pyridinium | 786638-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-methyl-1-(3-sulfopropyl)pyridinium
• 英文别名: Hydron;3-(4-methylpyridin-1-ium-1-yl)propane-1-sulfonate；hydron;3-(4-methylpyridin-1-ium-1-yl)propane-1-sulfonate
• CAS: 786638-04-8
• 化学式: C₉H₁₄NO₃S
• 分子量: 216.281
• InChiKey: MZRTWEBOYWBGCI-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methyl-1-(3-sulfopropyl)pyridinium 、 4-[N,N-双(2-羟乙基)氨基]苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以87%的产率得到
  参考文献：
  名称：

  一种吡啶磺酸内盐化合物及其制备方法和用 途

  摘要：

  本发明公开了一种吡啶磺酸内盐化合物及其制备方法和用途，其中吡啶磺酸内盐化合物的结构式为：本发明采用具有强给电子能力及较高反应活性的4‑(双(2‑羟乙基)氨基)苯甲醛与4‑甲基‑1‑(3‑磺酸基丙基)吡啶鎓进行反应，制备出具有良好水溶性和生物相容性的D–π–A型共轭结构的吡啶磺酸内盐化合物SL‑Neu，并以小鼠脑组织及其脊椎组织为材料进行激光共聚焦成像。该结果显示SL‑Neu能够特异性标记小鼠体内(小脑、中脑、脑回、海马体、脊椎)分布的神经细胞，可作为一种特异性标记神经细胞的近红外荧光探针。

  公开号：

  CN107987014B

文献信息

• LANTHANIDE COMPLEXES COMPRISING AT LEAST TWO BETAINE GROUPS, WHICH CAN BE USED AS LUMINESCENT MARKERS
  申请人：ECOLE NORMALE SUPERIEURE DE LYON

  公开号：US20160031910A1

  公开（公告）日：2016-02-04

  The present invention relates to luminescent lanthanide complexes including a chelating agent, formed with a macrocycle or a set of ligands, complexing a lanthanide ion Ln3+, wherein the chelating agent is substituted with at least two groups. The invention is most particularly applied to lanthanide complexes, the chelating agent of which is formed the with three ligands integrating a 2,6 pyridine-di(carboxylic acid) or is formed with a macrocycle having a 1,4,7 triazacyclononane structure.

  本发明涉及发光镧系络合物，包括一个螯合剂，由一个大环或一组配体形成，与镧系离子Ln3+形成络合物，其中螯合剂被至少两个基团取代。该发明特别适用于螯合剂由三个配体组成的镧系络合物，该配体集成了2,6-吡啶二（羧酸）或由具有1,4,7-三氮杂环壬烷结构的大环形成的。
• Selective detection of proteins that contain two or more alpha-helical transmembrane domains
  申请人：Patton F. Wayne

  公开号：US20060027455A1

  公开（公告）日：2006-02-09

  Embodiments of the present invention provide a staining solution and of method of using the staining solution for selectively detecting proteins that contain two or more α-helical transmembrane domains. The staining solution comprises a lipophilic dyes and at least about a 30% hydrophobic solvent. The dyes of the present are represented by the general formula A-B-E wherein A is a nitrogen heterocycle, B is a bridge moiety and E is an electron pair accepting moiety that comprises either a carbonyl or nitrogen atom. In one embodiment these lipophilic dyes are merocyanine dye, a cyanine dye, a styryl dye or a carbazolylvinyl dye.

  本发明的实施例提供了一种染色溶液和使用该染色溶液选择性检测含有两个或多个 α-螺旋跨膜结构域的蛋白质的方法。染色溶液包括亲脂性染料和至少约 30%的疏水性溶剂。本发明的染料由通式 A-B-E 表示，其中 A 是氮杂环，B 是桥基，E 是由羰基或氮原子组成的电子对接受基团。在一个实施方案中，这些亲脂性染料是美蓝染料、氰基染料、苯乙烯基染料或咔唑基乙烯基染料。
• MITTEL ZUM FÄRBEN VON KERATINHALTIGEN FASERN
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP1235549B1

  公开（公告）日：2006-11-29
• Selective Detection of Proteins that Contain Two or More Alpha-Helical Transmembrane Domains
  申请人：Patton Wayne F.

  公开号：US20100267078A1

  公开（公告）日：2010-10-21

  Embodiments of the present invention provide a staining solution and of method of using the staining solution for selectively detecting proteins that contain two or more α-helical transmembrane domains. The staining solution comprises a lipophilic dyes and at least about a 30% hydrophobic solvent. The dyes of the present are represented by the general formula A-B-E wherein A is a nitrogen heterocycle, B is a bridge moiety and E is an electron pair accepting moiety that comprises either a carbonyl or nitrogen atom. In one embodiment these lipophilic dyes are merocyanine dye, a cyanine dye, a styryl dye or a carbazolylvinyl dye.
• COMPOUNDS AND METHODS FOR OPTICAL SENSING OF ELECTRICAL ACTIVITY IN BIOLOGICAL SYSTEMS
  申请人：UNIVERSITY OF CONNECTICUT

  公开号：US20200362174A1

  公开（公告）日：2020-11-19

  Disclosed are tethered chromophore compositions comprising a membrane-spanning tether. The compounds can include covalently tethered fluorophore-quencher combinations useful for measuring action potentials and other fast electrical events in cells and tissues.