1-Phenyl-4-methyl-3-acetamido-pyrazolin | 77992-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenyl-4-methyl-3-acetamido-pyrazolin
• 英文别名: N-(4-Methyl-1-phenyl-2-pyrazolin-3-yl)acetamide；3-acetamido-4-methyl-1-phenyl-2-pyrazoline；N-(4-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-acetamide；N-(4-methyl-2-phenyl-3,4-dihydropyrazol-5-yl)acetamide
• CAS: 77992-39-3
• 化学式: C₁₂H₁₅N₃O
• 分子量: 217.271
• InChiKey: HJRIZOQAVQHOFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙烯腈 生成 1-Phenyl-4-methyl-3-acetamido-pyrazolin
  参考文献：
  名称：

  COPP, F. C.;EAKINS, K. E.

  摘要：

  DOI：

文献信息

• 3-Trifluoroacetylamino-1-aryl-2-pyrazolines
  申请人：American Cyanamid Company

  公开号：US04447442A1

  公开（公告）日：1984-05-08

  This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

  这份披露描述了新颖的3-取代氨基-1-苯基-2-吡唑烯和3-取代氨基-1-单取代和双取代苯基-2-吡唑烯及其C.sub.4和C.sub.5类似物，可用于改善关节炎疾病的炎症和/或进行性关节恶化特征，预防哮喘症状和过敏疾病的发作，或作为镇痛剂、抗菌剂或抗真菌剂。
• 3-Trifluoroacetyl amino-1-aryl-2-pyrazolines
  申请人：American Cyanamid Company

  公开号：US04348527A1

  公开（公告）日：1982-09-07

  This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, effective as anti-inflammatory and analgesic agents, and as antibacterial agents and/or antifungal agents.

  本披露描述了新型的3-取代氨基-1-苯基-2-吡唑烷和3-取代氨基-1-单取代和双取代苯基-2-吡唑烷及其C.sub.4和C.sub.5类似物，作为抗炎和镇痛剂以及抗菌剂和/或抗真菌剂具有有效性。
• Pharmaceutical compositions containing 3-Amino-pyrazoline derivatives
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0022578A1

  公开（公告）日：1981-01-21

  Heterocyclic compounds of formula (I) and their acid addition salts exhibit anti-inflammatory activity and when administered topically do not provide the side-effects associated with their systemic administration. The novel compounds of formula (I) may be prepared by methods known in the art and may be topically administered as the compound alone or in a suitable pharmaceutical formulation.

  式 (I) 的杂环化合物 及其酸加成盐具有抗炎活性，局部用药时不会产生与全身用药相关的副作用。式（I）的新型化合物可通过本领域已知的方法制备，并可作为化合物单独或在合适的药物制剂中局部给药。
• Heterocyclic substituted-amino-pyrazolines
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0070376A1

  公开（公告）日：1983-01-26

  Novel 3-amino and 3-substituted amino-1-substituted-2-pyrazolines and compositions of matter useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

  新颖的 3-氨基和 3-取代氨基-1-取代-2-吡唑啉类化合物和物质组合物，可用于改善关节炎疾病特有的炎症和/或进行性关节退化，预防哮喘症状和过敏性疾病的发生，或用作镇痛剂、抗菌剂或抗真菌剂。
• DUSZA, J. P.;JOSEPH, J. P.;BERNSTEIN, S.
  作者：DUSZA, J. P.、JOSEPH, J. P.、BERNSTEIN, S.

  DOI：——

  日期：——