N-(4-氯苯基)-2-羟基-9H-咔唑-3-甲酰胺 | 132-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-氯苯基)-2-羟基-9H-咔唑-3-甲酰胺
• 英文名称: AG-120-XIII
• 英文别名: Naphthol AS-LB；3-(4-Chlor-phenylcarbamoyl)-2-hydroxy-carbazol；2-Hydroxy-carbazol-3-carbonsaeure-(4-chlor-anilid)；N-(4-chlorophenyl)-2-hydroxy-9H-carbazole-3-carboxamide
• CAS: 132-61-6
• 化学式: C₁₉H₁₃ClN₂O₂
• 分子量: 336.777
• InChiKey: PPLNRTPNYCWODC-UHFFFAOYSA-N

物化性质

• 沸点：
  512.5±45.0 °C(Predicted)
• 密度：
  1.495±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.1
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

制备方法与用途

化学性质
该品的熔点为258-259℃，可溶于丁醇和吡啶，不溶于水，并微溶于碳酸钠溶液。在硫酸溶液中呈棕黄色，在氢氧化钠溶液中则变为黄色，还具有绿色荧光。

用途
主要用作棉织物染色和印花的打底剂。与一般色基偶合可获得红棕色、黄红色等色彩；与金属络合的冰染色基（如Variogen Base）偶合，则能产生蓝色，且牢度优异，色泽接近安安蓝。

生产方法
该品以咔唑和对氯苯胺为基本原料。首先，咔唑经发烟硫酸磺化后，用氢氧化钠进行碱熔；水解后，再用硫酸钠成盐，并用二氧化碳进行碳酸化，然后与碳酸钠反应成盐。接下来，与对氯苯胺及三氯化磷缩合，经过蒸馏、过滤和干燥而制得。

文献信息

• INFLAMMATORY CYTOKINE RELEASE INHIBITOR
  申请人：MUTO Susumu

  公开号：US20090192122A2

  公开（公告）日：2009-07-30

  A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-κB激活活性的药物，其包括以下通式(I)所表示的化合物或其药理学上可接受的盐作为活性成分：其中X代表连接基，A代表氢原子或乙酰基，E代表芳基或杂芳基，环X代表芳烃或杂芳烃。
• Inhibitors against the production and release of inflammatory cytokines
  申请人：——

  公开号：US20040259877A1

  公开（公告）日：2004-12-23

  A medicament having inhibitory activity against NF-&kgr;B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: 1 wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-&kgr;B激活活性的药物，其包括以下通式（I）所表示的化合物或其药学上可接受的盐作为活性成分：1其中X表示连接基，A表示氢原子或乙酰基，E表示芳基或杂芳基，环X表示芳烃或杂芳烃。
• INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES
  申请人：Institute of Medicinal Molecular Design, Inc.

  公开号：EP1352650A1

  公开（公告）日：2003-10-15

  A medicament having inhibitory activity against NF- κ B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种对 NF-κ B 活化具有抑制活性的药物，其活性成分包括下通式(I)所代表的化合物或药理学上可接受的盐： 其中，X 代表连接基团，A 代表氢原子或乙酰基，E 代表芳基或杂芳基，环 X 代表芳炔或杂芳炔。
• AMIDE, ARYL SULFONAMIDE, ARYL UREA, AND a,b-DIKETONE DERIVED CARBOXYLESTERASE INHIBITORS, AND THEIR METHODS OF USE
  申请人：Potter Philip M.

  公开号：US20080146548A1

  公开（公告）日：2008-06-19

  This disclosure relates to amides, aryl sulphonamides, aryl ureas, and α,β-diketones derivatives useful as carboxylesterase esterase inhibitors. The disclosure is also directed to the use of these compounds as selective human intestinal carboxylesterase inhibitors and insect carboxylesterase inhibitors. The disclosure is also directed to pharmaceutical compositions and pesticide formulations containing these compounds, and to methods for treating or ameliorating the toxic effects following administration of drugs such as cancer therapy drugs, treating or ameliorating the effects of a drug overdose, and to the use of the compounds for increasing the effectiveness of insecticides and pesticides.
• US3941768A
  申请人：——

  公开号：US3941768A

  公开（公告）日：1976-03-02