(5S)-5-methyl-1-[(3S)-1-[(2S)-2-(2-methylpropyl)-5-oxo-1,2-dihydropyrrol-3-yl]pyrrolidin-3-yl]pyrrolidine-2,4-dione | 1316848-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (5S)-5-methyl-1-[(3S)-1-[(2S)-2-(2-methylpropyl)-5-oxo-1,2-dihydropyrrol-3-yl]pyrrolidin-3-yl]pyrrolidine-2,4-dione
• CAS: 1316848-33-5
• 化学式: C₁₇H₂₅N₃O₃
• 分子量: 319.404
• InChiKey: FGMQDZXDXOWPLC-AVGNSLFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-4-(tert-butoxy)-5-((S)-sec-butyl)-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one 、 (5S)-5-methyl-1-[(3S)-1-[(2S)-2-(2-methylpropyl)-5-oxo-1,2-dihydropyrrol-3-yl]pyrrolidin-3-yl]pyrrolidine-2,4-dione 在 原甲酸三甲酯 作用下， 以 异丙醇 为溶剂， 反应 14.0h， 生成 (S)-4-(tert-butoxy)-5-((S)-sec-butyl)-1-((S)-1-((S)-1-((S)-1-((S)-2-isobutyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

  摘要：

  Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.

  DOI：

  10.1021/ja2033734
• 作为产物：
  描述：

  (S)-2-Isobutyl-3,5-dioxo-pyrrolidine-1-carboxylic acid tert-butyl ester 在 三氟乙酸 、 原甲酸三甲酯 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 8.5h， 生成 (5S)-5-methyl-1-[(3S)-1-[(2S)-2-(2-methylpropyl)-5-oxo-1,2-dihydropyrrol-3-yl]pyrrolidin-3-yl]pyrrolidine-2,4-dione
  参考文献：
  名称：

  Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

  摘要：

  Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.

  DOI：

  10.1021/ja2033734

文献信息

• PEPTIDOMIMETIC COMPOUNDS AND RELATED METHODS
  申请人：Burgess Kevin

  公开号：US20130288331A1

  公开（公告）日：2013-10-31

  Provided herein are compounds and methods of using same for the perturbation and/or inhibition of protein-protein interactions. Also provided herein is a data mining method useful for the identification of protein-protein interactions that may be inhibited by these compounds.