3-amino-4-methoxy-phenethylamine | 785025-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-4-methoxy-phenethylamine
• 英文别名: 3-Amino-4-methoxy-phenaethylamin；3-Amino-4-methoxy-β-phenaethylamin；5-(2-Aminoethyl)-2-methoxyphenylamine；5-(2-aminoethyl)-2-methoxyaniline
• CAS: 785025-71-0
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: BVYRPJPHBGCYDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,4-dimethoxy-2-nitro-phenyl)-acetyl chloride 、 3-amino-4-methoxy-phenethylamine 在 sodium hydroxide 、 苯 作用下， 生成 2-[2-(3,4-dimethoxy-2-nitro-phenyl)-acetylamino]-4-{2-[2-(3,4-dimethoxy-2-nitro-phenyl)-acetylamino]-ethyl}-1-methoxy-benzene
  参考文献：
  名称：

  Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

  摘要：

  N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter, The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03), There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001), This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS. (J. Endocrinol. Invest, 24: RC22-RC24, 2001) (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343878
• 作为产物：
  描述：

  2-(4-methoxy-3-nitrophenyl)ethane-1-amine 在 盐酸 、 溶剂黄146 、 tin(ll) chloride 作用下， 生成 3-amino-4-methoxy-phenethylamine
  参考文献：
  名称：

  Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients

  摘要：

  N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter, The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03), There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001), This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS. (J. Endocrinol. Invest, 24: RC22-RC24, 2001) (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343878

文献信息

• N2-(2-METHOXYPHENYL)PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：US20180111905A1

  公开（公告）日：2018-04-26

  The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.

  本发明涉及一种N2-(2-甲氧基苯基)嘧啶衍生物，其制备方法，以及包含其作为活性成分的用于预防或治疗癌症的药物组合物。本发明的N2-(2-甲氧基苯基)嘧啶衍生物，其光学异构体，或其药学上可接受的盐对抑制间变性淋巴瘤激酶（ALK）活性非常有效，从而可以提高对具有间变性淋巴瘤激酶（ALK）融合蛋白如EML4-ALK和NPM-ALK的癌细胞的治疗效果，因此可以有效地用作预防或治疗癌症的药物组合物。
• Inkjet ink compositions comprising polymeric dispersants having attached chromophore groups
  申请人：Shakhnovich Alexander I.

  公开号：US20070179213A1

  公开（公告）日：2007-08-02

  The present invention relates to an inkjet ink composition comprising a liquid vehicle, a pigment, and a polymeric dispersant. In one embodiment, the pigment comprises a colorant having the formula A-(B) x or is a carbon black pigment and the polymeric dispersant comprises a polymeric group and at least one group having the formula -A′-(B) y (C) z , wherein A and A′ are organic chromophore groups. In a second embodiment, the polymeric dispersant comprises a polymeric group and an organic chromophore group capable of interacting with the pigment.

  本发明涉及一种喷墨墨水组合物，其包括液体载体、颜料和聚合物分散剂。在一种实施例中，颜料包括具有A-(B)x式的色料，或者是碳黑颜料，聚合物分散剂包括聚合物基团和至少一个具有-A'-(B)y(C)z式的基团，其中A和A'是有机色团基团。在第二种实施例中，聚合物分散剂包括聚合物基团和能够与颜料相互作用的有机色团基团。
• Inkjet Ink Compositions Comprising Polymeric Dispersants Having Attached Chromophore Groups
  申请人：Shakhnovich Alexander I.

  公开号：US20110207860A1

  公开（公告）日：2011-08-25

  The present invention relates to an inkjet ink composition comprising a liquid vehicle, a pigment, and a polymeric dispersant. In one embodiment, the pigment comprises a colorant having the formula A-(B) x or is a carbon black pigment and the polymeric dispersant comprises a polymeric group and at least one group having the formula -A′-(B) y (C) z , wherein A and A′ are organic chromophore groups. In a second embodiment, the polymeric dispersant comprises a polymeric group and an organic chromophore group capable of interacting with the pigment.

  本发明涉及一种喷墨墨水组合物，包括液体载体、颜料和聚合物分散剂。在一种实施例中，颜料包括具有A-(B)x公式的着色剂，或者是碳黑颜料，聚合物分散剂包括聚合物基团和至少一个具有-A′-(B)y(C)z公式的基团，其中A和A′是有机色团基团。在第二种实施例中，聚合物分散剂包括聚合物基团和能够与颜料相互作用的有机色团基团。
• 7-[2-(Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0175525A1

  公开（公告）日：1986-03-26

  Compounds of the formula: and pharmaceutically acceptable salts are described in which: R is hydrogen, methyl or C2-6-alkanoyl; and R1 and R2 are, each, C1-6-alkyl, benzyl, phenethyl, methoxyphenethyl, hydroxyphenethyl or C2-6-alkanoyloxyphen- ethyl. The compounds are D2-dopamine agonists and have anti-hypertensive activity. Pharmaceutical compositions and methods of use are described, as are processes for their preparation.

  式中的化合物： 及药学上可接受的盐类，其中 R 是氢、甲基或 C2-6-烷酰基；以及 R1和R2各自为C1-6-烷基、苄基、苯乙基、甲氧基苯乙基、羟基苯乙基或C2-6-烷酰氧基苯乙基。 这些化合物是 D2-多巴胺激动剂，具有抗高血压活性。本文介绍了药物组合物和使用方法以及制备工艺。
• Slotta; Szyszka, Chemische Berichte, 1935, vol. 68, p. 184,187
  作者：Slotta、Szyszka

  DOI：——

  日期：——