2-tert-pentyl-thiophene | 10421-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-tert-pentyl-thiophene
• 英文别名: 2-tert-Pentyl-thiophen；2-(2-Methylbutan-2-yl)thiophene
• CAS: 10421-56-4
• 化学式: C₉H₁₄S
• 分子量: 154.276
• InChiKey: IISLAZKHNIRSPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-tert-pentyl-thiophene 在 三氯化铝 、 Petroleum ether 作用下， 生成 1-(5-tert-pentyl-[2]thienyl)-ethanone-(2,4-dinitro-phenylhydrazone)
  参考文献：
  名称：

  Hydrogen Transfer. IV.¹ Reaction of p-Isobutyltoluene and of p-s-Butyltoluene with Methylcyclohexene

  摘要：

  DOI：

  10.1021/ja01160a038
• 作为产物：
  描述：

  噻吩 、 2-甲基-2-丁烯 在 乙基磺酸 作用下， 生成 2-tert-pentyl-thiophene
  参考文献：
  名称：

  Hydrogen Transfer. IV.¹ Reaction of p-Isobutyltoluene and of p-s-Butyltoluene with Methylcyclohexene

  摘要：

  DOI：

  10.1021/ja01160a038

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：PHARMASSET INC

  公开号：WO2012075140A1

  公开（公告）日：2012-06-07

  Disclosed herein are 2'-spiro-nucleosides of formula I and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus. Formula (I), where z is a four-or five-membered ring selected from among radicals a-o represented by de following structures (II) where * represents the point of attachment to the 2'-carbon.

  本文披露了公式I的2'-螺环核苷及其衍生物，用于治疗感染丙型肝炎病毒或登革病毒的受试者。公式(I)中，z是从以下结构(II)所代表的基团a-o中选择的四元或五元环。其中*表示连接到2'-碳的位置。
• Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
  申请人：Bolea Christelle

  公开号：US20110257182A1

  公开（公告）日：2011-10-20

  The present invention relates to novel compounds of Formula (I), wherein X 1 , X 2 , X 3 , X 4 , A m and B n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及一种新型的化合物，其化学式为(I)，其中X1、X2、X3、X4、A和Bn的定义如化学式(I)中所示；发明的化合物是代谢型谷氨酸受体亚型4（“mGluR4”）的调节剂，可用于治疗或预防中枢神经系统疾病以及其他由mGluR4受体调节的疾病。本发明还涉及制药组合物以及使用这些化合物制备药物的方法，以及使用这些化合物预防和治疗涉及mGluR4的疾病的方法。
• COMPOUNDS
  申请人：DU JINFA

  公开号：US20120142626A1

  公开（公告）日：2012-06-07

  Disclosed herein are 2′-spiro-nucleosides and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus.

  本文公开了2'-螺环核苷及其衍生物，用于治疗感染丙型肝炎病毒或登革热病毒的患者。
• 2'-SPIRO-NUCLEOSIDES FOR USE IN THE THERAPY OF HEPATITIS C
  申请人：Gilead Pharmasset LLC

  公开号：EP3042910A2

  公开（公告）日：2016-07-13

  Disclosed herein are 2'-spiro-nucleosides of formula I and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus, wherein B is selected from among B2 and B3 represented by the following structures:

  本文公开了式 I 的 2'-spiro-nucleosides 及其衍生物，可用于治疗丙型肝炎病毒或登革热病毒感染者、 其中 B 选自以下结构代表的 B2 和 B3：
• Resist composition, method of forming resist pattern, polymeric compound, and compound
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US11061329B2

  公开（公告）日：2021-07-13

  A resist composition including a resin component having a structural unit derived form a compound represented by formula (a0-1) (in the formula, W represents a polymerizable group-containing group; Ra01 is a group which is bonded to Ra03 to form an aliphatic cyclic group, or bonded to Ra04 to form an aliphatic cyclic group; Ra02 represents a hydrocarbon group which may have a substituent; Ra03 is a hydrogen atom or a monovalent organic group in the case where Ra01 is not bonded thereto; Ra04 is a hydrogen atom or a monovalent organic group in the case where Ra01 is not bonded thereto; and Ra05 to Ra07 each independently represents a hydrogen atom or a monovalent organic group).

  一种抗蚀剂组合物，包括一种树脂组分，其结构单元衍生自式(a0-1)所代表的化合物（式中，W 代表含可聚合基团的基团；Ra01 是与 Ra03 键合形成脂肪族环状基团的基团，或与 Ra04 键合形成脂肪族环状基团的基团； Ra02 代表可能具有取代基的烃基；Ra03 是氢原子或一价有机基团（在 Ra01 未与之键合的情况下）；Ra04 是氢原子或一价有机基团（在 Ra01 未与之键合的情况下）；以及 Ra05 至 Ra07 各自独立地代表氢原子或一价有机基团）。