avermectin B_2a | 65195-57-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: avermectin B_2a
• 英文别名: (1R,4S,4'S,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-butan-2-yl-4',21,24-trihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• CAS: 65195-57-5
• 化学式: C₄₈H₇₄O₁₅
• 分子量: 891.107
• InChiKey: CWGATOJEFAKFBK-QJDTYEMPSA-N

物化性质

• 沸点：
  966.4±65.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  63
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  190
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  avermectin B_2a 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 2.5h， 以81%的产率得到deoleandro-avermectin B2A
  参考文献：
  名称：

  Avermectin aglycons

  摘要：

  DOI：

  10.1021/jo00342a023

文献信息

• Avermectin derivatives
  申请人：——

  公开号：US20040087519A1

  公开（公告）日：2004-05-06

  A compound represented by the general formula (I) or a salt thereof: 1 wherein, —X Y— represents —CH═CH—, —CH 2 —CH 2 — or the like, between R 1 and the carbon atom at 4′-position represents a single bond or a double bond, between R 2 and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when —X Y— represents —CH═CH— or —CH 2 —CH 2 —, and between R 1 and the carbon atom at 4′-position represents a double bond, R 1 represents ═C(R 11 )(R 12 ) (wherein R 11 represents a lower alkyl group or the like and R 12 represents a hydrogen atom or the like) or the like, and R 2 represents a hydroxyl group or the like, or R 2 may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when —X Y— represents —CH═CH— or —CH 2 —CH 2 —, and between R 1 and the carbon atom at 4′-position represents a single bond, R 1 represents —OCH(R 1a )(R 1b ) (wherein R 1a represents a lower alkyl or the like and R 1b represents a hydrogen atom or the like) or the like, and R 2 represents a hydroxyl group or the like.

  通式(I)表示的化合物或其盐：其中，—XY—代表—CH═CH—，—CH2—CH2—或类似结构，R1与4'-位置的碳原子之间表示单键或双键，R2与5-位置的碳原子之间表示单键或双键，例如，1）当—XY—代表—CH═CH—或—CH2—CH2—时，且R1与4'-位置的碳原子之间表示双键时，R1代表═C(R11)(R12)（其中R11代表较低的烷基或类似结构，R12代表氢原子或类似结构）或类似结构，R2代表羟基或类似结构，或R2可以与5-位置的碳原子结合形成羰基，2）当—XY—代表—CH═CH—或—CH2—CH2—时，且R1与4'-位置的碳原子之间表示单键时，R1代表—OCH(R1a)(R1b)（其中R1a代表较低的烷基或类似结构，R1b代表氢原子或类似结构）或类似结构，R2代表羟基或类似结构。
• DIMERIC AVERMECTIN AND MILBEMYCIN DERIVATIVES
  申请人：Meng Charles Q.

  公开号：US20100144859A1

  公开（公告）日：2010-06-10

  This invention provides for novel antiparasitic and pesticidal derivatives of avermectin and milbemycin compounds in which two avermectin or milbemycin members are linked together by a chemical linker. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections and infestations in animals or for combating pests in plants or plant propagation material.

  这项发明提供了一种新颖的阿维菌素和米氏菌素衍生物，其中两个阿维菌素或米氏菌素成员通过化学连接剂连接在一起。所得的化合物可用于兽药组合物中，用于治疗、控制和预防动物体内和体外寄生虫感染及寄生虫侵染，或用于对抗植物或植物繁殖材料中的害虫。
• AVERMECTIN DERIVATIVES
  申请人：Jeschke Peter

  公开号：US20100234312A1

  公开（公告）日：2010-09-16

  Novel avermectin derivatives of the formula (I) in which —C 22 R 1 -A-C 23 R 2 , R 3 , R 4 and R 5 have the meanings given in the description, processes for preparing these compounds and their use for controlling animal pests, and also novel intermediates and their preparation

  本发明涉及一种新的阿维菌素衍生物，其化学式为（I），其中—C22R1-A-C23R2，R3，R4和R5的含义如描述所述，本发明还涉及制备这些化合物的方法、用于控制动物害虫的方法，以及新的中间体及其制备方法。
• Materials and methods for killing nematodes and nematode eggs
  申请人：——

  公开号：US20020016330A1

  公开（公告）日：2002-02-07

  Methods and compositions for the control of nematodes are disclosed. Specifically, the subject anthelmintic compounds have been found to advantageously control nematodes at concentrations which are non-phytotoxic. The anthelmintic compounds can be used in conjunction with other nematicidal agents such as free fatty acids, fatty acid salts, avermectins, ivermectin, and milbemycin.

  本发明揭示了控制线虫的方法和组合物。具体而言，已发现该类驱虫剂化合物可以在非植物毒性浓度下有效地控制线虫。该类驱虫剂化合物可以与其他线虫杀虫剂（如游离脂肪酸、脂肪酸盐、阿维菌素、伊维菌素和米尔贝霉素）一起使用。
• Synergistic Combination of Glutamate-and Gaba-Gated Chloride Agonist Pesticide and at Least One Vitamin E, Niacin, or Derivatives Thereof
  申请人：Pedersen Morten

  公开号：US20090111759A1

  公开（公告）日：2009-04-30

  Presented are pesticidal compositions comprising at least one pesticide selected among Glutamate- or GABA-gated chloride channel agonist pesticides and at least one synergist which is selected among Vitamin E, Niacin and derivatives thereof. The combinations of these compounds show a synergistic effect allowing a composition to be prepared comprising a lesser amount of pesticide, while still controlling the harmful pests.

  提供的是杀虫组合物，包括至少一种从谷氨酸或GABA门控氯离子通道激动剂杀虫剂中选择的杀虫剂，以及至少一种从维生素E、烟酸及其衍生物中选择的协同剂。这些化合物的组合表现出协同效应，允许制备含较少杀虫剂的组合物，同时仍然控制有害的害虫。