N-(4-Methylbenzylidene)-4-methylthioaniline | 197905-60-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-(4-Methylbenzylidene)-4-methylthioaniline
• 英文别名: 1-(4-methylphenyl)-N-(4-methylsulfanylphenyl)methanimine
• CAS: 197905-60-5
• 化学式: C₁₅H₁₅NS
• 分子量: 241.357
• InChiKey: ANOMTBWPCMQLTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-Methylbenzylidene)-4-methylthioaniline 在 水 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以72%的产率得到N-(4-methylbenzyl)-4-methylthioaniline
  参考文献：
  名称：

  Cathode enabled high faradaic efficiency: reduction of imines to amines with H₂O as a H-source

  摘要：

  使用H2O作为H源，通过电化学还原亚胺制备胺。通过使用碳纸阴极调节反应，抑制不需要的HER（水的电化学分解），从而实现高法拉第效率。

  DOI：

  10.1039/d2cc03479d
• 作为产物：
  描述：

  对甲基苯甲醛 、 4-氨基茴香硫醚 以90%的产率得到N-(4-Methylbenzylidene)-4-methylthioaniline
  参考文献：
  名称：

  1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

  摘要：

  A series of 1,5-diarylimidazoles with 4-methylsulfonylphenyl group were prepared and evaluated for the inhibitory activities against COX-2 catalyzed PGE(2) production from LPS-induced RAW 264.7 cells. Most of synthesized 1,5-diarylimidazoles exhibited strong inhibitory activities regardless of the position of the 4-methylsulfonylphenyl group. The 1,5-diarylimidazoles with a halogen atom (3c-3h, 3n-3p) gave mostly excellent inhibitory activities regardless of the position and species of the halogen atom. Whereas the 1,5-diarylimidazoles with two fluorine atoms (3k, 3l, 3r, 3s) showed rather reduced inhibitory activities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.092

文献信息

• 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic
  申请人：Sankyo Company, Limited

  公开号：US05908858A1

  公开（公告）日：1999-06-01

  Compounds of formula (I) and (II): ##STR1## \x9bwherein R is hydrogen, halogen or alkyl; R.sup.1 is alkyl, amino or substituted amino; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen, halogen or optionally substituted alkyl; R.sup.4 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl! have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.

  式(I)和(II)的化合物：##STR1## 其中R为氢、卤素或烷基；R.sup.1为烷基、氨基或取代氨基；R.sup.2为可选取代的苯基；R.sup.3为氢、卤素或可选取代的烷基；R.sup.4为氢、可选取代的烷基、环烷基、芳基或芳基烷基！具有有价值的镇痛、抗炎、退烧和抗过敏活性，并具有抑制白三烯产生和抑制骨吸收的能力。它们相对于一般具有这些活性的化合物的副作用较少。
• USRE039420E1
  申请人：——

  公开号：——

  公开（公告）日：——
• 1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells
  作者：Haiyan Che、Truong Ngoc Tuyen、Hyun Pyo Kim、Haeil Park

  DOI：10.1016/j.bmcl.2010.05.092

  日期：2010.7

  A series of 1,5-diarylimidazoles with 4-methylsulfonylphenyl group were prepared and evaluated for the inhibitory activities against COX-2 catalyzed PGE(2) production from LPS-induced RAW 264.7 cells. Most of synthesized 1,5-diarylimidazoles exhibited strong inhibitory activities regardless of the position of the 4-methylsulfonylphenyl group. The 1,5-diarylimidazoles with a halogen atom (3c-3h, 3n-3p) gave mostly excellent inhibitory activities regardless of the position and species of the halogen atom. Whereas the 1,5-diarylimidazoles with two fluorine atoms (3k, 3l, 3r, 3s) showed rather reduced inhibitory activities. (C) 2010 Elsevier Ltd. All rights reserved.
• Cathode enabled high faradaic efficiency: reduction of imines to amines with H₂O as a H-source
  作者：Aihua Wang、Xin Liu、Wei Gao、Li Ma、Siyuan Liu、Guofeng Zhang、Mingyang Zhou、Xiaofei Jia、Jianbin Chen

  DOI：10.1039/d2cc03479d

  日期：——

  An electrochemical reduction of imines to amines is developed using H₂O as a H-source. By tuning the reaction by using a carbon paper cathode, the undesired HER is suppressed, thereby achieving high faradaic efficiency.

  使用H2O作为H源，通过电化学还原亚胺制备胺。通过使用碳纸阴极调节反应，抑制不需要的HER（水的电化学分解），从而实现高法拉第效率。