isopropyl 6-O-[6'-O-[6''-O-(benzyl)-2'',3'',4''-trideoxy-4''-amino-α-D-erythro-hex-2''-enopyranosyl]-2',3',4'-trideoxy-4'-amino-α-D-erythro-hex-2'-enopyranosyl]-2,3,4-trideoxy-4-amino-α-D-erythro-hex-2-enopyranoside | 1033614-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: isopropyl 6-O-[6'-O-[6''-O-(benzyl)-2'',3'',4''-trideoxy-4''-amino-α-D-erythro-hex-2''-enopyranosyl]-2',3',4'-trideoxy-4'-amino-α-D-erythro-hex-2'-enopyranosyl]-2,3,4-trideoxy-4-amino-α-D-erythro-hex-2-enopyranoside
• 英文别名: (2S,3S,6S)-6-[[(2S,3S,6S)-3-amino-6-[[(2S,3S,6S)-3-amino-6-propan-2-yloxy-3,6-dihydro-2H-pyran-2-yl]methoxy]-3,6-dihydro-2H-pyran-2-yl]methoxy]-2-(phenylmethoxymethyl)-3,6-dihydro-2H-pyran-3-amine
• CAS: 1033614-80-0
• 化学式: C₂₈H₄₁N₃O₇
• 分子量: 531.649
• InChiKey: BKGLCTSGALUUIV-LFTLWYAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  isopropyl 6-O-[6'-O-[6''-O-(benzyl)-2'',3'',4''-trideoxy-4''-(N-nosylamino)-α-D-erythro-hex-2''-enopyranosyl]-2',3',4'-trideoxy-4'-(N-nosylamino)-α-D-erythro-hex-2'-enopyranosyl]-2,3,4-trideoxy-4-(N-nosylamino)-α-D-erythro-hex-2-enopyranoside 在 potassium carbonate 、 苯硫酚 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以65%的产率得到isopropyl 6-O-[6'-O-[6''-O-(benzyl)-2'',3'',4''-trideoxy-4''-amino-α-D-erythro-hex-2''-enopyranosyl]-2',3',4'-trideoxy-4'-amino-α-D-erythro-hex-2'-enopyranosyl]-2,3,4-trideoxy-4-amino-α-D-erythro-hex-2-enopyranoside
  参考文献：
  名称：

  Stereoselective Synthesis of 2,3-Unsaturated 1,6-Oligosaccharides by Means of a Glycal-Derived Allyl Epoxide and N-Nosyl Aziridine

  摘要：

  beta-D-threo- and 4-deoxy-4-amino-alpha-D-erythro-hex-2-enopyranosyl di- (n = 0) and trisaccharides (n = 1) of types A and B were synthetized by means of a reiterative, completely stereoselective glycosylation process which makes use of the D-galactal-derived allyl epoxide 1 beta and D-allal-derived allyl N-nosyl aziridine 2 alpha, respectively.

  DOI：

  10.1021/ol800793f

文献信息

• Stereoselective Synthesis of 2,3-Unsaturated 1,6-Oligosaccharides by Means of a Glycal-Derived Allyl Epoxide and <i>N</i>-Nosyl Aziridine
  作者：Valeria Di Bussolo、Lorenzo Checchia、Maria Rosaria Romano、Mauro Pineschi、Paolo Crotti

  DOI：10.1021/ol800793f

  日期：2008.6.1

  beta-D-threo- and 4-deoxy-4-amino-alpha-D-erythro-hex-2-enopyranosyl di- (n = 0) and trisaccharides (n = 1) of types A and B were synthetized by means of a reiterative, completely stereoselective glycosylation process which makes use of the D-galactal-derived allyl epoxide 1 beta and D-allal-derived allyl N-nosyl aziridine 2 alpha, respectively.